Evidence map›Paper›PMID 42272296›Full record

ArticleSmall methods2026

Pyrene Derivative-Based Electrode for Electrochemical Sensing.

Ana R Santos, Fátima Bento, Bruno Faria, Maria C Paiva, Alexandre F Silva, Ana S Viana, Júlio C Viana

Erratum issuedAbstract read
In one paragraph

Article in Small methods, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Ana R SantosIPC - Institute for Polymers and Composites, Campus De Azurém, University of Minho, Guimarães, Portugal.ORCID https://orcid.org/0000-0002-8380-2142
Fátima BentoCampus De Gualtar, CQ-UM - Chemistry Research Centre of the University of Minho, Braga, Portugal.ORCID https://orcid.org/0000-0003-0106-2089
Bruno FariaIPC - Institute for Polymers and Composites, Campus De Azurém, University of Minho, Guimarães, Portugal.
Maria C PaivaIPC - Institute for Polymers and Composites, Campus De Azurém, University of Minho, Guimarães, Portugal.
Alexandre F SilvaCMEMS - Center for Microelectromechanical Systems, Campus De Azurém, University of Minho, Guimarães, Portugal.
Ana S VianaCentro de Química Estrutural, Faculdade de Ciências, Universidade De Lisboa, Campo Grande, Lisbon, Portugal.
Júlio C VianaIPC - Institute for Polymers and Composites, Campus De Azurém, University of Minho, Guimarães, Portugal.

Funding

Portuguese Fundação para a Ciência e Tecnologia (FCT) 2021.07771.BDPortuguese Fundação para a Ciência e Tecnologia (FCT) UID/00100/2025Portuguese Fundação para a Ciência e Tecnologia (FCT) UIDB/05256/2020Portuguese Fundação para a Ciência e Tecnologia (FCT) UIDP/05256/2020
6 · The paper itself

Abstract

In this work, screen-printed carbon electrodes were modified with a pyrene derivative (PY) to enhance their electrochemical sensing performance. Their applicability was demonstrated in cortisol detection, used here as a model biomarker. This derivative consists of a pyrene functionalized with a pendant group containing a carboxyl function bonded to an aromatic moiety through an amide linkage. The electrode's performance in relation to cortisol was assessed using differential pulse voltammetry (DPV). The results demonstrate the potential of this PY-based electrode as a simple electrochemical sensing platform without the need for biological recognition elements or molecular probes. Molecular dynamics (MD) simulations provided molecular-level insights into the interactions between the pyrene derivative and cortisol. Overall, the study highlights the potential applicability of this pyrene derivative in the development of low-cost electrochemical sensing platforms and simplified detection protocols.

Indexed as

Electrochemical TechniquesHydrocortisonePyrenesBiosensing TechniquesCarbonElectrodesMolecular Dynamics SimulationCarbonHydrocortisonepyrenePyreneselectrochemical sensingmolecular dynamicspyrene derivativessurface functionalization

Identifiers

PMID42272296
PMCPMC13353889

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.