Oxygen-Tolerant Photo-Induced Miniaturized Accelerated Atom Transfer Radical Polymerization (OPTIMA-ATRP) for High-Throughput Synthesis of Polymer Bioconjugates.

Arman Moini Jazani, Roksana Wygoda, Hironobu Murata, Mozhdeh Madadi, Grzegorz Przesławski, Krzysztof Matyjaszewski

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Article in Angewandte Chemie (International ed. in English), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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6 authors.

Arman Moini JazaniDepartment of Chemistry, Carnegie Mellon University, Pittsburgh, USA.

Roksana WygodaDepartment of Chemistry, Carnegie Mellon University, Pittsburgh, USA.ORCID 0000-0003-2439-4246

Hironobu MurataDepartment of Chemistry, Carnegie Mellon University, Pittsburgh, USA.

Mozhdeh MadadiDepartment of Chemistry, Carnegie Mellon University, Pittsburgh, USA.

Grzegorz PrzesławskiDepartment of Chemistry, Carnegie Mellon University, Pittsburgh, USA.ORCID 0000-0002-7188-4013

Krzysztof MatyjaszewskiDepartment of Chemistry, Carnegie Mellon University, Pittsburgh, USA.ORCID 0000-0003-1960-3402

Funding

Division of Materials Researchfrom NSF DMR 2202747the Fonds de recherche du Québec 301734

6 · The paper itself

Abstract

Conjugates of synthetic polymers with biomolecules, forming polymer bioconjugates (PBCs), are used to improve the pharmacokinetic properties of many biological therapeutics. Growing synthetic polymers from biomolecules via reversible deactivation radical polymerization (RDRP) demonstrated enormous potential as an alternative to the "grafting to" method in synthesizing biohybrids. However, conventional "grafting from" approaches applied to biomolecules are hindered by large reaction volumes, long reaction times, rigorous deoxygenation, and complex workflows, rendering them unsuitable for synthesizing libraries of PBCs needed to collect large data sets for emerging materials discovery. Herein, Oxygen-tolerant photo-induced miniaturized accelerated atom transfer radical polymerization (OPTIMA-ATRP) in water was developed for the polymerization of hydrophilic (meth)acrylate monomers under ambient or sub-ambient (4°C) temperature and atmospheric conditions, without prior degassing, in < 10 min. Sodium pyruvate (SP) in conjunction with UV light (380-395 nm, 28.5-30 mW/cm

Indexed as

OxygenPolymersFree RadicalsHigh-Throughput Screening AssaysPhotochemical ProcessesPolymerizationUltraviolet RaysFree RadicalsOxygenPolymersaqueous radical polymerizationhigh‐throughput polymer synthesisoxygen‐tolerant controlled radical polymerizationphoto‐atom transfer radical polymerizationprotein–polymer hybrids

Identifiers

PMID42272180

DOI10.1002/anie.6617585

PMCPMC13452573

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