Evidence map›Paper›PMID 42272081›Full record

ArticleBirth defects research2026

Opportunities and Challenges for Surveillance of Congenital Anomalies in Sub-Saharan Africa.

Emma Kalk, Helen Louise Malherbe, Ushma C Mehta, Daniel Mumpe-Mwanja, Modiegi Dianah Diseko, Adejumoke Idowu Ayede, Phyllis Kisa, George Bello, Caroline Bonareri Osoro, Lee Fairlie and 9 more

Erratum issuedAbstract read
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Article in Birth defects research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

19 authors.

Emma KalkCentre for Integrated Data and Epidemiological Research, School of Public Health, University of Cape Town, Cape Town, South Africa.ORCID 0000-0001-7706-6866
Helen Louise MalherbeCentre for Human Metabolomics, Desmond Tutu School of Medicine, Faculty of Health Sciences, North-West University, Potchefstroom, South Africa.ORCID 0000-0002-9566-6248
Ushma C MehtaDivision of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa.ORCID 0000-0002-0032-3171
Daniel Mumpe-MwanjaMakerere University-Johns Hopkins University Research Collaboration (MU-JHU), Kampala, Uganda.ORCID 0000-0002-5670-5371
Modiegi Dianah DisekoBotswana Harvard Health Partnership, Gaborone, Botswana.
Adejumoke Idowu AyedeDepartment of Paediatrics, College of Medicine, University of Ibadan and University College Hospital, Ibadan, Nigeria and Centre for African Newborn Health and Nutrition, University College Hospital, Ibadan, Nigeria.
Phyllis KisaMakerere University College of Health Sciences, Kampala, Uganda.
George BelloInternational Training and Education Centre, Malawi and Ministry of Health, Public Health Institute of Malawi, Lilongwe, Malawi.ORCID 0000-0003-1257-619X
Caroline Bonareri OsoroCentre for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya.ORCID 0000-0003-2867-6224
Lee FairlieWits RHI, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
Audrey ChepkemoiMoi Teaching and Referral Hospital, Eldoret, Kenya.
Hamisi K ShabaniMuhimbili Orthopaedic Institute, Dar es Salaam, Tanzania.ORCID 0000-0002-0966-1062
Ali SieCentre de Recherche en Santé de Nouna, Nouna, Burkina Faso.
Samrawit Abebaw TegeneHararghe Health Research, Haramaya University, Harar, Ethiopia.
Robert SerunjogiMakerere University-Johns Hopkins University Research Collaboration (MU-JHU), Kampala, Uganda.ORCID 0000-0002-8694-1359
Aminkeng Zawuo LekeCentre for Maternal and Infant Research, Health Research Foundation (HRF), Buea, Cameroon.ORCID 0000-0001-7268-6820
Helen DolkSchool of Medicine, Ulster University, Belfast, UK.
Linda Barlow MoshaMakerere University-Johns Hopkins University Research Collaboration (MU-JHU), Kampala, Uganda.
sub‐Saharan African Congenital Anomalies Network (sSCAN)

Funding

Gates Foundation INV-004508UK Research and Innovation MR/T039132/1
6 · The paper itself

Abstract

introductionCongenital anomalies (CA) are ranked as the 3rd and 4th leading cause of neonatal and under-5 mortality, respectively. Over 30% of infants born with a serious CA are found in sub-Saharan Africa. Yet there are few robust epidemiological data on the burden and distribution of CA and associated mortality, disability, and morbidity, which limits research and investment in clinical and public health interventions. The sub-Saharan African Congenital Anomalies Network (sSCAN) was established in 2021 to address the fragmented research, surveillance, and care programmes for children with CA in the region.

methodsThe sSCAN established a community of practice with the long-term aim to promote the prevention and early diagnosis of CA and care for children and families, determining prevalence, promoting preventive interventions, and improving health outcomes by: (1) Sharing resources and multidisciplinary expertise; (2) Establishing a common response to public health questions; (3) Pooling and comparing data between countries; (4) Capacity building.

resultsThe sSCAN includes 16 projects across 12 countries, in addition to other stakeholders in sub-Saharan Africa. Most projects are fully or jointly supported by donor partners with a specific disease/exposure focus: collaboration within Africa is uncommon. Lack of data harmonization, varied funding streams and related data access, and country- and institution-specific data-protection legislation limited regional data sharing. The sSCAN has hosted 15 webinars which are available with other resources on the website, and supported grant applications and publications.

conclusionThe sSCAN platform can provide opportunities to build capacity, share expertise, and optimize data use toward contextually-relevant solutions for CA in sub-Saharan Africa.

Indexed as

Congenital AbnormalitiesAfrica South of the SaharaHumansInfantInfant, NewbornPopulation SurveillancePrevalencePublic HealthSub-Saharan African Peoplecommunity of practicecongenital anomaliesregional networksub‐Saharan Africasurveillance

Identifiers

PMID42272081
PMCPMC13254227

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.