Evidence map›Paper›PMID 42271653›Full record

ArticlePrenatal diagnosis2026

Placental Dysfunction and Congenital Heart Disease: Investigating the Placenta-Heart Axis.

Natalie Lanners, Sarah U Morton, Katherine Le, Steffy Blanco, Sara Mansoorshahi, Chrystalle Katte Carreon, Christina Ronai, Louise Wilkins-Haug, Vidhya Annavajjhala, Jacqueline G Parchem and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Prenatal diagnosis, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Natalie LannersMcGovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas, USA.ORCID https://orcid.org/0009-0003-3641-4563
Sarah U MortonDepartment of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA.ORCID https://orcid.org/0000-0002-7816-2646
Katherine LeMcGovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas, USA.
Steffy BlancoDepartment of Pediatrics, Division of Neonatal-Perinatal Medicine, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas, USA.
Sara MansoorshahiMcGovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas, USA.
Chrystalle Katte CarreonDepartment of Pathology, Boston Children's Hospital, Boston, Massachusetts, USA.
Christina RonaiDepartment of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA.ORCID https://orcid.org/0000-0002-1503-7100
Louise Wilkins-HaugDivision of Maternal-Fetal Medicine and Reproductive Genetics, Brigham and Women's Hospital, Boston, Massachusetts, USA.ORCID https://orcid.org/0000-0001-6077-0953
Vidhya AnnavajjhalaDepartment of Pediatrics, Division of Pediatric Cardiology, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas, USA.
Jacqueline G ParchemDepartment of Obstetrics, Gynecology and Reproductive Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas, USA.ORCID https://orcid.org/0000-0002-4795-3488
Tina O FindleyDepartment of Pediatrics, Division of Neonatal-Perinatal Medicine, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveConcurrent development of the placenta and heart during early gestation suggests a shared biological basis for the co-occurrence of abnormal placentation and congenital heart disease (CHD). This study investigated the association between placental vascular pathology and CHD type.

methodsA retrospective study at two institutions included CHD (n = 521) and unaffected (n = 122) infants. CHDs were categorized into three groups (left and right ventricular outflow tract obstruction and mixed lesions) based on the anticipated effect of placental venous return streaming toward the fetal brain. Placental pathological findings were categorized by the Amsterdam criteria. The rate of placental pathology was compared between cases and controls and across the three CHD groups.

resultsCHD had higher rates of maternal vascular malperfusion (MVM) (0.31 vs. 0.05, p < 0.001). Comparison within CHD groups demonstrated similar rates of MVM, while fetal vascular malperfusion (FVM) was significantly higher in groups with reduced fetal cerebral oxygenation (p = 0.037). MVM was associated with low birth weight (OR = 0.28, p < 0.001), and FVM was associated with increased maternal age (OR = 1.07, p = 0.037). No significant associations were identified in other placental pathologies.

conclusionThis study offers valuable insights into the connection between placental dysfunction and CHD, identifying that MVM is significantly associated with CHD development.

Indexed as

Heart Defects, CongenitalPlacentaPlacenta DiseasesAdultCase-Control StudiesFemaleHumansInfant, NewbornPregnancyRetrospective Studies

Identifiers

PMID42271653
PMCPMC13377307

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.