ArticleThe Journal of dermatology2026
Phenotypic Analysis of 26 Cultured TILs Derived From Japanese Melanoma Tissues.
Article in The Journal of dermatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Immunotherapy in Asia: current insights and prospects in Southeast Asia and Malaysia.Frontiers in oncology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors.
Funding
Abstract
purposeTumor-infiltrating lymphocyte (TIL) therapy has attracted increasing attention as a promising next-generation cancer immunotherapy that may overcome some limitations of current immune checkpoint inhibitors. However, the phenotypic characteristics and tumor reactivity of TILs derived from Japanese melanoma tissues remain insufficiently investigated. This study aimed to evaluate the feasibility of expanding TILs from Japanese melanoma specimens and to characterize their phenotype and autologous tumor reactivity.
methodsTILs were expanded from 26 Japanese melanoma specimens, including tumors derived from primary and mucosal lesions. The phenotypes of cultured TILs were assessed, and reactivity against autologous tumor cells was evaluated in 9 available TIL samples.
resultsTILs were successfully expanded from Japanese melanoma tissues, consistent with previous reports from the United States. The phenotypes of cultured TILs varied substantially among cases. Among the 9 TIL samples tested for reactivity against autologous tumor cells, MHC class I-restricted specific reactivity was detected in 7 samples, including 1 sample derived from mucosal melanoma. No clear association was observed between autologous tumor reactivity and the proportion of CD3
conclusionThis study is the first to characterize cultured TILs established from a series of Japanese melanoma patients. These findings suggest that the expansion of tumor-reactive TILs from Japanese melanoma tissues is feasible and may provide a basis for the development of TIL therapy in Japan.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.