Evidence map›Paper›PMID 42271525›Full record

ArticleAntimicrobial resistance and infection control2026

Multidrug-resistant organism carriage in Vietnamese district hospitals before and after an antimicrobial stewardship intervention.

Jaslyn Doshi, Thai Duy Pham, Yen Ngoc Pham, Thuy Thu Ma, Linh Thuy Duong, Qingbin Li, Thanh Ha Nguyen, Matthew Watts, Jon Iredell, Thu Anh Nguyen and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antimicrobial resistance and infection control, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Jaslyn DoshiFaculty of Medicine and Health, The University of Sydney, Sydney, Australia. jaslyn.doshi@sydney.edu.au.
Thai Duy PhamNational Institute of Hygiene and Epidemiology (NIHE), Hanoi, Vietnam.
Yen Ngoc PhamThe University of Sydney Vietnam Institute, Hanoi, Vietnam.
Thuy Thu MaThe University of Sydney Vietnam Institute, Hanoi, Vietnam.
Linh Thuy DuongThe University of Sydney Vietnam Institute, Hanoi, Vietnam.
Qingbin LiFaculty of Medicine and Health, The University of Sydney, Sydney, Australia.
Thanh Ha NguyenNational Institute of Hygiene and Epidemiology (NIHE), Hanoi, Vietnam.
Matthew WattsCentre for Infectious Diseases and Microbiology Laboratory Services, NSW Health Pathology-Institute of Clinical Pathology and Medical Research (ICPMR), Westmead, Sydney, Australia.
Jon IredellCentre for Infectious Diseases and Microbiology Laboratory Services, NSW Health Pathology-Institute of Clinical Pathology and Medical Research (ICPMR), Westmead, Sydney, Australia.
Thu Anh NguyenFaculty of Medicine and Health, The University of Sydney, Sydney, Australia.
Hoang Huy TranNational Institute of Hygiene and Epidemiology (NIHE), Hanoi, Vietnam.
Greg J Fox *Faculty of Medicine and Health, The University of Sydney, Sydney, Australia.
Annaleise R Howard-Jones *Sydney Infectious Diseases Institute (Sydney ID), The University of Sydney, Sydney, Australia.

Funding

Department of Foreign Affairs and Trade, Australian Government 1153346National Health and Medical Research Council 2007920
6 · The paper itself

Abstract

introductionAntimicrobial resistance is a critical global health challenge, with Southeast Asia identified as a hotspot of multidrug-resistant organism (MRO) carriage in hospitalised patients and the general population. This study aimed to estimate the prevalence of gastrointestinal and nasal MRO carriage among district hospital inpatients in Vietnam and assess changes following an antimicrobial stewardship (AMS) intervention.

methodsTwo repeated cross-sectional prevalence surveys were conducted among inpatients at four district hospitals in Vietnam (two urban hospitals in Hanoi and two rural hospitals in Ca Mau). The baseline survey was undertaken immediately prior to implementation of a 6-month AMS intervention (March 2022), and the post-intervention survey was conducted during the final 2 weeks of the intervention (August 2022). The intervention bundle comprised establishing hospital AMS committees and teams, implementing antimicrobial prescribing guidelines, healthcare worker education, and regular antimicrobial prescribing audits with feedback to clinicians. Carriage of extended spectrum β-lactamase (ESBL)-producing Enterobacterales and carbapenemase-producing Enterobacterales (CPE) was determined from stool or rectal swabs, and methicillin-resistant Staphylococcus aureus (MRSA) carriage using nasal swabs. MROs were characterised using phenotypic antimicrobial susceptibility testing and molecular analyses. A participant questionnaire assessed demographic, behavioural and healthcare-related risk factors. Pre- and post-intervention prevalence estimates were compared using two-proportion tests. Mixed-effects binary regression models were used to identify risk factors for ESBL-producing Enterobacterales carriage.

resultsA total of 402 participants (ages 18-99 years, M:F 176:226) provided nasal swabs and rectal or stool samples across both surveys. Participant demographics differed modestly between surveys. Overall, 76.1% of participants carried Enterobacterales isolates harbouring bla

conclusionESBL-producing Enterobacterales carriage was highly prevalent among inpatients in four Vietnamese district hospitals, while CPE and MRSA carriage remained low. A 6-month AMS intervention was associated with a modest reduction in MRSA carriage but no change in ESBL-producing Enterobacterales or CPE carriage.

Indexed as

Antimicrobial StewardshipCarrier StateDrug Resistance, Multiple, BacterialAdolescentAdultAgedAged, 80 and overAnti-Bacterial AgentsCross-Sectional StudiesEnterobacteriaceaeFecesFemaleHospitals, DistrictHumansMaleMethicillin-Resistant Staphylococcus aureusAnti-Bacterial AgentsAntimicrobial resistanceAntimicrobial stewardshipCarbapenemase-producing EnterobacteralesDistrict hospitalsExtended-spectrum beta-lactamaseMethicillin-resistant Staphylococcus aureusMultidrug-resistant organismVietnam

Identifiers

PMID42271525
PMCPMC13479839

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.