Evidence map›Paper›PMID 42271454›Full record

ArticleCell communication and signaling : CCS2026

Oncometabolite 2-hydroxyglutarate destabilizes CDH1 to regulate quiescence and enhance chemotherapy sensitivity.

Hai-Hui Zhang, Xiang-Tian Chen, Si-Qi Li, Xin-Lei Yan, Meng Wang, Yan Lin, Yi-Yuan Yuan, Yun-Zi Mao, Jie Liu, Wei Xu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell communication and signaling : CCS, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Hai-Hui ZhangThe Obstetrics & Gynecology Hospital of Fudan University, Shanghai Key Lab of Reproduction and Development, Shanghai Key Lab of Female Reproductive Endocrine Related Diseases, and Institutes of Biomedical Sciences, Fudan University, Shanghai, 200438, China.
Xiang-Tian ChenThe Obstetrics & Gynecology Hospital of Fudan University, Shanghai Key Lab of Reproduction and Development, Shanghai Key Lab of Female Reproductive Endocrine Related Diseases, and Institutes of Biomedical Sciences, Fudan University, Shanghai, 200438, China.
Si-Qi LiThe Obstetrics & Gynecology Hospital of Fudan University, Shanghai Key Lab of Reproduction and Development, Shanghai Key Lab of Female Reproductive Endocrine Related Diseases, and Institutes of Biomedical Sciences, Fudan University, Shanghai, 200438, China.
Xin-Lei YanThe Obstetrics & Gynecology Hospital of Fudan University, Shanghai Key Lab of Reproduction and Development, Shanghai Key Lab of Female Reproductive Endocrine Related Diseases, and Institutes of Biomedical Sciences, Fudan University, Shanghai, 200438, China.
Meng WangThe Obstetrics & Gynecology Hospital of Fudan University, Shanghai Key Lab of Reproduction and Development, Shanghai Key Lab of Female Reproductive Endocrine Related Diseases, and Institutes of Biomedical Sciences, Fudan University, Shanghai, 200438, China.
Yan LinThe Obstetrics & Gynecology Hospital of Fudan University, Shanghai Key Lab of Reproduction and Development, Shanghai Key Lab of Female Reproductive Endocrine Related Diseases, and Institutes of Biomedical Sciences, Fudan University, Shanghai, 200438, China.
Yi-Yuan YuanThe Obstetrics & Gynecology Hospital of Fudan University, Shanghai Key Lab of Reproduction and Development, Shanghai Key Lab of Female Reproductive Endocrine Related Diseases, and Institutes of Biomedical Sciences, Fudan University, Shanghai, 200438, China.
Yun-Zi MaoThe Obstetrics & Gynecology Hospital of Fudan University, Shanghai Key Lab of Reproduction and Development, Shanghai Key Lab of Female Reproductive Endocrine Related Diseases, and Institutes of Biomedical Sciences, Fudan University, Shanghai, 200438, China.
Jie LiuDepartment of Digestive Diseases of Huashan Hospital, Fudan University, Shanghai, 200438, P.R. China. jieliu@fudan.edu.cn.
Wei XuThe Obstetrics & Gynecology Hospital of Fudan University, Shanghai Key Lab of Reproduction and Development, Shanghai Key Lab of Female Reproductive Endocrine Related Diseases, and Institutes of Biomedical Sciences, Fudan University, Shanghai, 200438, China. xuwei_0706@fudan.edu.cn.

Funding

National Key Research and Development Program of China 2024YFA1306002National Key Research and Development Program of China 2024YFA1802700National Key Research and Development Program of China 2024YFA1803504National Natural Science Foundation of China 32230054National Natural Science Foundation of China 32400635National Natural Science Foundation of China 92357301
6 · The paper itself

Abstract

Isocitrate dehydrogenase 1 mutation IDH1

Indexed as

Antigens, CDCadherinsCdh1 ProteinsGlutaratesAnimalsAntineoplastic AgentsCell Line, TumorDrug Resistance, NeoplasmGlioblastomaHumansMicePhosphorylationProtein StabilityUbiquitinationalpha-hydroxyglutarateAntigens, CDAntineoplastic AgentsCadherinsCDH1 protein, humanCdh1 ProteinsGlutarates

Identifiers

PMID42271454
PMCPMC13474960

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.