Evidence map›Paper›PMID 42271452›Full record

ArticleCardiovascular diabetology2026

Increased epicardial adipose tissue area and radiodensity in sarcopenic obesity.

Tianwen He, Ruilin Wang, Wenhua Jiang, Rongna Lian, Xiaomei Chen, Ming Yang

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Article in Cardiovascular diabetology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Tianwen He *Center of Gerontology and Geriatrics, State Key Laboratory of Respiratory Health and Multimorbidity, West China Hospital, Sichuan University, No 37 Guoxue Lane, Chengdu, Sichuan, 610041, China.
Ruilin Wang *Department of Dermatology and Venereology, West China Hospital, Sichuan University, Chengdu, China.
Wenhua JiangWest China School of Public Health, Sichuan University, Chengdu, China.
Rongna LianCenter of Gerontology and Geriatrics, State Key Laboratory of Respiratory Health and Multimorbidity, West China Hospital, Sichuan University, No 37 Guoxue Lane, Chengdu, Sichuan, 610041, China.
Xiaomei ChenDepartment of Dermatology and Venereology, West China Hospital, Sichuan University, Chengdu, China. chemmeir2008@126.com.
Ming YangCenter of Gerontology and Geriatrics, State Key Laboratory of Respiratory Health and Multimorbidity, West China Hospital, Sichuan University, No 37 Guoxue Lane, Chengdu, Sichuan, 610041, China. yangmier@gmail.com.

Funding

1·3·5 Project of the State Key Laboratory of Respiratory Health and Multimorbidity, West China Hospital RHM25212
6 · The paper itself

Abstract

backgroundSarcopenic obesity (SO) confers substantially greater cardiometabolic risk than either sarcopenia or obesity alone, but the tissue-level structural alterations underlying this risk remain unclear. Epicardial adipose tissue (EAT) characteristics, including both area and radiodensity, may provide clinically relevant insight into the cardiometabolic burden associated with this complex muscle-fat imbalance.

methodsWe conducted a cross-sectional study of 1678 adults undergoing health examinations. Participants were categorized into normal, sarcopenia, obesity, and SO phenotypes based on the European Society for Clinical Nutrition and Metabolism and the European Association for the Study of Obesity (ESPEN/EASO) conceptual framework. Body composition and grip strength were assessed according to the Asian Working Group for Sarcopenia (AWGS) 2025 criteria. EAT area (cm

resultsThe SO phenotype was identified in 45 individuals. Following multivariable adjustment, SO was independently associated with a larger EAT area (beta = 6.93 cm

conclusionsIn this cross-sectional study, SO was associated with larger EAT area and higher EAT radiodensity. These findings support the presence of a distinct EAT phenotype in SO and suggest that CT-derived EAT measures may be useful imaging markers that warrant prospective validation.

Indexed as

AdiposityEpicardial Adipose TissueObesitySarcopeniaTomography, X-Ray ComputedAgedCross-Sectional StudiesFemaleHand StrengthHumansMaleMiddle AgedPhenotypePredictive Value of TestsRisk AssessmentBody compositionComputed tomographyEpicardial adipose tissueMuscle functionSarcopenic obesity

Identifiers

PMID42271452
PMCPMC13474757

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.