ArticleClinical epigenetics2026
CRONDEX: a web-based platform for exploring links between chromatin-related genes and neurodevelopmental disorders.
Article in Clinical epigenetics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
backgroundChromatin regulatory genes are essential for orchestrating neurodevelopment by controlling DNA accessibility and the expression of genes required for neuronal differentiation and maturation. Mutations affecting these regulators-including histone modifiers, chromatin remodelers, and chromatin-binding factors-are a major cause of neurodevelopmental disorders (NDDs), many of which display overlapping yet mechanistically heterogeneous clinical features. As the catalogue of chromatin-related NDD genes has expanded, so too has the availability of phenotypic, functional, and pathway annotations. However, these data remain dispersed across multiple resources, making it difficult to integrate them in order to systematically compare genes or explore shared mechanisms. Existing platforms such as the Human Phenotype Ontology and the Monarch Initiative offer powerful phenotype-gene mapping tools, but they operate across the full genomic space and do not provide the focused framework needed to examine chromatin-related NDD genes as a coherent group.
resultsWe present CRONDEX (ChROmatin and NeuroDevelopmental disorder-related genes EXploratory platform), a user-friendly web resource developed to meet this need by supporting integrative exploration of relationships among chromatin-related genes implicated in NDDs. The database was constructed by intersecting curated chromatin (EpiFactors) and neurodevelopmental (SysNDD+Orphanet+SFARI+NDD-GeneHub) gene sets while excluding transcription factors, and enriched with annotations from Gene Ontology, KEGG, and the Human Phenotype Ontology. CRONDEX provides two complementary query modes: (i) a Gene-Based Query, which identifies genes with phenotypic profiles similar to a user-defined target using Jaccard similarity metrics; and (ii) a Criteria-Based Query, which retrieves genes matching specific phenotypic, functional, or pathway filters. Through representative examples, we show how the Gene-Based Query recovers biologically coherent relationships-from paralogous pairs such as CREBBP-EP300 to functionally convergent modules like the BAFopathies-while the Criteria-Based Query enables hypothesis-driven exploration, exemplified by the intersection of thermogenesis and chromatin-related NDDs, and by chromatin-binding genes linked to status epilepticus. By enabling rapid, integrative, and hypothesis-oriented analyses, CRONDEX facilitates the discovery of shared mechanisms across chromatin-related NDDs and supports both basic and translational research. The platform is freely accessible at https://jgf-bioinfo.shinyapps.io/CRONDEX/ .
conclusionCRONDEX provides a domain-focused platform that enables phenotype-guided exploration of chromatin-related genes, supporting mechanistic hypothesis generation in NDDs.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.