ArticleCell & bioscience2026
Multi-omic analysis reveals Wharton's jelly mesenchymal stem cells shift the pro-inflammatory phenotype of fibroblast subpopulation to induce skin rejuvenation.
Article in Cell & bioscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
backgroundSkin aging is an increasingly serious clinical problem with limited treatment options. Wharton's jelly mesenchymal stem cells (WJMSCs) represent a promising regenerative strategy. However, their mechanisms of action remain to be fully elucidated through integrated multi-omics approaches.
methodsWe established D-galactose-induced aging models using human dermal fibroblasts (HDFs) and nude mice. The effects of WJMSC transplantation were evaluated through functional assays, histology, bulk RNA-seq, microarray, and single-cell transcriptomics. Key pathways and cellular subpopulations were further investigated via bioinformatic integration and experimental validation.
resultsIn vitro, WJMSC conditioned medium restored cellular functions-enhancing proliferation, migration, and reducing ROS and SA-β-gal activity. Systemic administration of WJMSCs reversed skin thinning, increased collagen deposition, rebalanced collagen I/III ratios, and reduced cell senescence. Additionally, WJMSCs promoted M2 macrophage polarization, angiogenesis, and Lgr6
conclusionsHerein, we have provided comprehensive multi-omics evidence demonstrating that WJMSCs counteract skin aging through functional restoration, immunomodulation, and by altering the gene expression profiles of fibroblast subpopulations. These data have revealed potential therapeutic targets influenced by WJMSCs for remodeling fibroblast subpopulations in skin aging, and have provided new insights for precise cell-based interventions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.