ArticleRespiratory research2026
Peripheral immune profiling identifies CD8⁺ T
Article in Respiratory research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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9 authors.
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Abstract
backgroundImmune checkpoint inhibitors (ICIs) have demonstrated substantial clinical benefits in advanced non-small cell lung cancer (NSCLC); however, a subset of patients experience early disease progression despite PD-L1 expression, highlighting the need for biomarkers that better reflect systemic immune competence. We performed comprehensive peripheral immune profiling of patients with advanced NSCLC receiving first-line ICI therapy.
methodsBlood samples were collected from patients with advanced NSCLC prior to the initiation of first-line ICI-based therapy. A total of 23 lymphocyte subsets and 13 soluble immune-related factors were analyzed, and multivariate models were used to identify independent prognostic biomarkers.
resultsA total of 74 patients with advanced NSCLC who received first-line ICI therapy were included in this study, none of whom harbored EGFR, ALK, or ROS1 mutations. In multivariate analyses, elevated CD4⁺ T cell immunoreceptor with Ig and ITIM domains (TIGIT)⁺ frequencies independently predicted shorter progression-free survival (hazard ratio (HR) = 3.74, p < 0.001), along with increased CD8⁺ terminally differentiated effector memory T cells re-expressing CD45RA (T
conclusionsBaseline frequencies of peripheral CD4⁺ T TIGIT⁺ and CD8⁺ T
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