Evidence map›Paper›PMID 42271386›Full record

ArticleJournal of nanobiotechnology2026

Dual-responsive polypyridyl Ru(II)-scaffolded hydrogel for trinitarian tumor therapy activated by mono-wavelength photo-irradiation.

Zhendong Chen, Jiao Zhou, Sizhen Wang, Tianheng Chen, Francisco Aznarez, Xintong Yan, Xiaoxiao Hu, Yiling Xia, Linhong Sun, Chen Wang and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Zhendong Chen *Department of Inorganic Chemistry, School of Pharmacy, Naval Medical University, 325 Guohe Road, Shanghai, 200433, China.
Jiao Zhou *Department of Inorganic Chemistry, School of Pharmacy, Naval Medical University, 325 Guohe Road, Shanghai, 200433, China.
Sizhen Wang *Department of Inorganic Chemistry, School of Pharmacy, Naval Medical University, 325 Guohe Road, Shanghai, 200433, China.
Tianheng Chen *Department of Inorganic Chemistry, School of Pharmacy, Naval Medical University, 325 Guohe Road, Shanghai, 200433, China.
Francisco AznarezDepartment of Chemistry, Fudan University, 220 Handan Road, Shanghai, 200433, China.
Xintong YanDepartment of Inorganic Chemistry, School of Pharmacy, Naval Medical University, 325 Guohe Road, Shanghai, 200433, China.
Xiaoxiao HuDepartment of Inorganic Chemistry, School of Pharmacy, Naval Medical University, 325 Guohe Road, Shanghai, 200433, China.
Yiling XiaDepartment of Inorganic Chemistry, School of Pharmacy, Naval Medical University, 325 Guohe Road, Shanghai, 200433, China.
Linhong SunDepartment of Inorganic Chemistry, School of Pharmacy, Naval Medical University, 325 Guohe Road, Shanghai, 200433, China.
Chen WangDepartment of Oncology, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, 1665 Kongjiang Road, Shanghai, 200092, China. wangchenchina@126.com.
Feng YangDepartment of Inorganic Chemistry, School of Pharmacy, Naval Medical University, 325 Guohe Road, Shanghai, 200433, China. Yangfeng1008@126.com.
Beibei GuoDepartment of Inorganic Chemistry, School of Pharmacy, Naval Medical University, 325 Guohe Road, Shanghai, 200433, China. bbguo1994@163.com.

Funding

National Natural Science Foundation of China 82304455National Natural Science Foundation of China 82473891
6 · The paper itself

Abstract

Metal-coordinated hydrogels offer a strategy to integrate local drug retention, responsive release, and multimodal therapy, but assigning structural and therapeutic roles to a single metal complex remains challenging. Here, we report an injectable polypyridyl Ru(II)-scaffolded hydrogel, Ru(fmb)

Indexed as

HydrogelsRutheniumAnimalsCell Line, TumorHumansIndolesInfrared RaysMiceNanoparticlesPhotochemotherapyPhotosensitizing AgentsPolymersReactive Oxygen SpeciesTumor Microenvironment2-(2-(2-chloro-3-((1,3-dihydro-3,3-dimethyl-1-propyl-2H-indol-2-ylidene)ethylidene)-1-cyclohexen-1-yl)ethenyl)-3,3-dimethyl-1-propylindoliumHydrogelsIndolesPhotosensitizing AgentspolydopaminePolymersReactive Oxygen SpeciesRutheniumChemodynamic therapyDual-responsivePhotodynamic therapyPhotothermal therapyPolypyridyl Ru(II)-scaffolded hydrogel

Identifiers

PMID42271386
PMCPMC13474838

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.