Evidence map›Paper›PMID 42271351›Full record

ArticleCancer cell international2026

RANBP1 promotes oral cancer progression through activating YAP1 and NDUFB3 derived from the database of single-cell sequencing.

Wei-Chen Yen, Shu-Chen Liu, Shih-Sheng Jiang, Chia-Yu Yang, Fang-Yu Tsai, Tzu-Tung Liu, Yun-Hua Sui, Meng-Hsin Li, Hsing-Wen Cheng, Jui-Shan Yi and 5 more

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Article in Cancer cell international, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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15 authors.

Wei-Chen Yen *Department of Otolaryngology-Head and Neck Surgery, Chang Gung Memorial Hospital Linkou, Taoyuan, Taiwan.
Shu-Chen Liu *Department of Biomedical Sciences and Engineering, National Central University, Taoyuan, Taiwan.
Shih-Sheng JiangNational Institute of Cancer Research, National Health Research Institutes, Miaoli, Taiwan.
Chia-Yu YangDepartment of Otolaryngology-Head and Neck Surgery, Chang Gung Memorial Hospital Linkou, Taoyuan, Taiwan.
Fang-Yu TsaiNational Institute of Cancer Research, National Health Research Institutes, Miaoli, Taiwan.
Tzu-Tung LiuDepartment of Biomedical Sciences and Engineering, National Central University, Taoyuan, Taiwan.
Yun-Hua SuiDepartment of Biomedical Sciences and Engineering, National Central University, Taoyuan, Taiwan.
Meng-Hsin LiDepartment of Biomedical Sciences and Engineering, National Central University, Taoyuan, Taiwan.
Hsing-Wen ChengDepartment of Otolaryngology-Head and Neck Surgery, Chang Gung Memorial Hospital Linkou, Taoyuan, Taiwan.
Jui-Shan YiDepartment of Otolaryngology-Head and Neck Surgery, Chang Gung Memorial Hospital Linkou, Taoyuan, Taiwan.
Chi-Yin LeeDepartment of Otolaryngology-Head and Neck Surgery, Chang Gung Memorial Hospital Linkou, Taoyuan, Taiwan.
Wan-Ling WangDepartment of Microbiology and Immunology, College of Medicine, Chang Gung University, Taoyuan, Taiwan.
Tsung-You TsaiDepartment of Otolaryngology-Head and Neck Surgery, Chang Gung Memorial Hospital Linkou, Taoyuan, Taiwan.
Yenlin HuangDepartment of Pathology, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
Kai-Ping ChangDepartment of Otolaryngology-Head and Neck Surgery, Chang Gung Memorial Hospital Linkou, Taoyuan, Taiwan. dr.kpchang@gmail.com.

Funding

Chang Gung Memorial Hospital CMRPG3M0103Ministry of Science and Technology, Taiwan NSTC 111-2314-B-182A-078-MY3Ministry of Science and Technology, Taiwan NSTC 112-2314-B-008-001-MY3
6 · The paper itself

Abstract

Oral cavity squamous cell carcinoma (OSCC) is the most common head and neck cancer, thriving in microenvironments composed of cancer cells, stromal tissue, and extracellular matrix. Extensive local invasion and cervical nodal metastasis can lead to poor treatment outcomes for OSCC. We created a single-cell transcriptomic database of OSCC using biopsies from 10 individuals to identify candidate genes. Ran-specific binding protein 1 (RANBP1) was identified as a gene with differential expression between malignant and normal epithelial cells. Analysis of the Cancer Genome Atlas Program (TCGA) OSCC and Taiwanese cohorts confirmed that higher RANBP1 levels are significantly associated with worse prognosis. Functional tests showed that knocking down RANBP1 reduced cell proliferation and invasion by decreasing proteins involved in focal adhesion, invadopodia formation, and epithelial-mesenchymal transition. Inhibiting RANBP1 also decreased vascular spread in zebrafish tumor xenografts, while overexpressing RANBP1 had the opposite effect. The overexpression of RANBP1 significantly increased tumor growth in NOD/SCID xenografts. RANBP1 was positively correlated with the oxidative phosphorylation pathway. Cells with reduced RANBP1 showed lower levels of NADH ubiquinone oxidoreductase subunit B3 (NDUFB3) and had impaired mitochondrial function. Additionally, RANBP1 depletion decreased activation of Yes1 associated transcriptional regulator (YAP1). Increased NDUFB3 expression in RANBP1-overexpressing cells was reversed by YAP1 inhibitor verteporfin treatment or knocking down YAP1. RANBP1 enhances a more invasive microenvironment of OSCC.

Indexed as

NDUFB3Oral cancerOxidative phosphorylationRANBP1YAP1

Identifiers

PMID42271351
PMCPMC13480108

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