Evidence map›Paper›PMID 42271284›Full record

ArticleBMC psychiatry2026

Functional alterations of the medial frontal gyrus as candidate biomarkers for resilience in major depressive disorder.

Feng Li, Qijing Bo, Zhenzhu Chen, Chuanyue Wang, Zhifang Zhang

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Article in BMC psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

5 authors.

Feng LiBeijing Key Laboratory of Intelligent Drug Research and Development for Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, 100088, China.
Qijing BoBeijing Key Laboratory of Intelligent Drug Research and Development for Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, 100088, China.
Zhenzhu ChenBeijing Key Laboratory of Intelligent Drug Research and Development for Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, 100088, China.
Chuanyue WangBeijing Key Laboratory of Intelligent Drug Research and Development for Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, 100088, China. wang.cy@163.net.
Zhifang ZhangBeijing Key Laboratory of Intelligent Drug Research and Development for Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing, 100088, China. zhifangzhang@ccmu.edu.cn.

Funding

Beijing Hospital Authority Youth Program QML20231907Capital Medical University PYZ25178Capital Medical University Research and Cultivation Fund PYZ22157
6 · The paper itself

Abstract

backgroundMajor depressive disorder (MDD) is a prevalent psychiatric condition; however, candidate neural substrates related to resilience to MDD remain unclear.

methodsResting-state functional magnetic resonance imaging (fMRI) data were collected from 113 patients with MDD, 36 unaffected siblings, and 81 healthy controls (HCs). First, degree centrality (DC) analysis was performed to identify group differences. Next, regions showing significant DC differences were used as seeds for whole-brain functional connectivity (FC) analyses. Finally, associations between these significant brain regions and depressive symptom severity were examined separately within each participant group.

resultsDC in the medial frontal gyrus and the right precentral gyrus, as well as FC between the medial frontal gyrus and the right postcentral gyrus, exhibited the pattern: patients with MDD < HCs < unaffected siblings. Correlation analyses revealed no significant relationships between depressive symptom severity and DC or FC values.

conclusionsUnaffected siblings exhibited both the highest DC and the strongest FC related to the medial frontal gyrus. These neuroimaging findings provide further insight into the role of the medial frontal gyrus in potential resilience mechanisms and suggest potential directions for the prevention and treatment of MDD.

Indexed as

Major Depressive DisorderPrefrontal CortexResilience, PsychologicalAdultBiomarkersCase-Control StudiesFemaleHumansMagnetic Resonance ImagingMaleSiblingsYoung AdultBiomarkersBrain functionFunctional magnetic resonance imagingMajor depressive disorderResilienceUnaffected siblings

Identifiers

PMID42271284
PMCPMC13479556

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.