Observational studyBMC pregnancy and childbirth2026
The association between adverse perinatal outcomes, obstructive sleep apnoea and the role of depressive symptoms.
Observational study in BMC pregnancy and childbirth, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Fetal and neonatal outcomes of pregnancies complicated by maternal sleep-disordered breathing: a systematic review.Frontiers in physiology · 2026Pooled it
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBoth obstructive sleep apnoea (OSA) and depressive symptoms have been independently associated with adverse perinatal outcomes. However, defining the individual contribution of each condition to adverse perinatal outcomes is difficult because many pregnant women with OSA also have depressive symptoms. This observational study aimed to investigate the relationship between OSA in pregnancy and perinatal outcomes, accounting for the confounding effects of depressive symptoms.
methodsOne hundred twenty two pregnant women (≥ 26 weeks' gestation) from a tertiary maternity hospital completed overnight monitoring of oxygen saturation and airflow and reported depressive symptoms. Medical records were reviewed, and maternal and newborn outcomes recorded. Binary logistic regression assessed the association of maternal and newborn outcomes with OSA, accounting for depressive symptoms.
resultsNewborns of mothers with OSA had 18 times the odds of having an Apgar score of < 7 at 5 min after birth after accounting for depressive symptoms and body mass index (aOR 18.41, 95% CI 1.17-289.29). Mothers with more frequent dips in oxygenation > 3% had higher birthweight infants after accounting for BMI and depressive symptoms (β = 0.75, 95% CI 0.20-1.29; p = 0.008). Women with depressive symptoms were almost 7 times more likely to have a preterm infant (aOR 6.85, 95% CI 1.57-29.95). Maternal OSA was not associated with gestational hypertensive disorders, gestational diabetes or caesarean delivery.
conclusionsThis study shows OSA relates to newborns with low Apgar scores after birth, while depressive symptoms relate to preterm birth. Considering this both psychological interventions and OSA treatment may be valuable in improving perinatal mental health and infant wellbeing.
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