Evidence map›Paper›PMID 42271251›Full record

ArticleBMC anesthesiology2026

Considerations for diverse RYR1 variants in malignant hyperthermia susceptible patients: a report of two cases.

Yan Fang, Wei Mei, Jiangjiang Bi

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC anesthesiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Yan FangDepartment of Anesthesiology, Hubei Key Laboratory of Geriatric Anesthesia and Perioperative Brain Health, and Wuhan Clinical Research Center for Geriatric Anesthesia, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Wei MeiDepartment of Anesthesiology, Hubei Key Laboratory of Geriatric Anesthesia and Perioperative Brain Health, and Wuhan Clinical Research Center for Geriatric Anesthesia, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Jiangjiang BiDepartment of Anesthesiology, Hubei Key Laboratory of Geriatric Anesthesia and Perioperative Brain Health, and Wuhan Clinical Research Center for Geriatric Anesthesia, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. bessie8210@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Malignant hyperthermia (MH) is an autosomal dominant pharmacogenetic disorder primarily triggered by halogenated volatile anesthetics, succinylcholine, or cisatracurium. This report describes two cases exhibiting typical MH symptoms, including hyperthermia, hypercarbia, tachycardia, and acidosis, but with notable differences in the time of onset and symptom severity. The variable expression of MH may be influenced by multiple factors, such as the potency of the triggering agent, its dosage, the duration of exposure, and the "incomplete penetrance" of genetic variants. The novel RYR1 gene variants reported in this study may contribute to the Genomic Variant Database for this condition.

Indexed as

Malignant HyperthermiaRyanodine Receptor Calcium Release ChannelAdultFemaleGenetic Predisposition to DiseaseGenetic VariationHumansMaleYoung AdultRyanodine Receptor Calcium Release ChannelRYR1 protein, humanGeneral anesthesiaGene variantsIncomplete penetranceMalignant hyperthermiaScoliosis

Identifiers

PMID42271251
PMCPMC13474918

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.