Evidence map›Paper›PMID 42271227›Full record

ArticleBMC genomics2026

Comprehensive analysis of HB-PHD transcription factors associated with drought and salt stresses in wheat.

Zhaosashuang Tian, Zilin Fan, Yuyi Ma, Xin Sun, Xu Lu, Xinxin Hong, Hao Liu, Fa Cui, Yanhong Zhao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC genomics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Zhaosashuang Tian *Yantai Key Laboratory of Molecular Breeding for High-Yield and Stress-Resistant Crops and Efficient Cultivation/College of Horticulture, Ludong University, Yantai, 264000, China.
Zilin Fan *Yantai Key Laboratory of Molecular Breeding for High-Yield and Stress-Resistant Crops and Efficient Cultivation/College of Horticulture, Ludong University, Yantai, 264000, China.
Yuyi MaYantai Key Laboratory of Molecular Breeding for High-Yield and Stress-Resistant Crops and Efficient Cultivation/College of Horticulture, Ludong University, Yantai, 264000, China.
Xin SunYantai Key Laboratory of Molecular Breeding for High-Yield and Stress-Resistant Crops and Efficient Cultivation/College of Horticulture, Ludong University, Yantai, 264000, China.
Xu LuYantai Key Laboratory of Molecular Breeding for High-Yield and Stress-Resistant Crops and Efficient Cultivation/College of Horticulture, Ludong University, Yantai, 264000, China.
Xinxin HongCollege of Fisheries, Ludong University, Yantai, 264000, China.
Hao LiuYantai Key Laboratory of Molecular Breeding for High-Yield and Stress-Resistant Crops and Efficient Cultivation/College of Horticulture, Ludong University, Yantai, 264000, China. liuhao_1990@126.com.
Fa CuiYantai Key Laboratory of Molecular Breeding for High-Yield and Stress-Resistant Crops and Efficient Cultivation/College of Horticulture, Ludong University, Yantai, 264000, China. sdaucf@126.com.
Yanhong ZhaoYantai Key Laboratory of Molecular Breeding for High-Yield and Stress-Resistant Crops and Efficient Cultivation/College of Horticulture, Ludong University, Yantai, 264000, China. zyhbob@163.com.

Funding

Key Technology Research and Development Program of Shandong Province 2024LZGCQY012National Natural Science Foundation of China 32272159Natural Science Foundation of Shandong Province ZR2025QC235Taishan Scholar Program of Shandong Province 20230119
6 · The paper itself

Abstract

backgroundHB-PHD transcription factors play important roles in plant growth and development as well as stress response. However, comprehensive analysis of HB-PHD genes was not investigated in wheat.

resultsIn this study, a total of nine TaHB-PHD genes were identified in wheat at the genome-wide level, and their physicochemical properties, evolutionary relationships, gene structures, cis-acting elements, expression patterns, downstream genes, and drought-resistant superior haplotypes were systematically analyzed. Phylogenetic analysis showed that HB-PHD proteins were divided into five subfamilies, and TaHB-PHD genes belonged to subfamilies Ⅰ,Ⅱ, and Ⅴ. The gene structures and conserved motifs of members in the same subfamily were highly conserved. Tissue expression analysis revealed that TaHB-PHD genes had the highest expression levels in roots and the lowest in leaves. Under drought stress, the cultivar-specific expression pattern was observed, all TaHB-PHD genes were down-regulated in drought-tolerant cultivar Giza168, and up-regulated in Chinese Spring and drought-sensitive cultivar Gemmiza10. Under salt stress, TaHB-PHD1-A/B/D and TaHB-PHD3-A/B/D were up-regulated, while the expression of TaHB-PHD2-A/B/D showed no obvious change. Prediction of downstream genes found that TaHB-PHDs could regulate various genes such as ribosomal RNA methyltransferase and histone acetyltransferase to participate in stress responses. Haplotype analysis indicated that TaHB-PHD3-D-Hap I was a drought-resistant superior haplotype.

conclusionsThis study provides a theoretical basis and candidate genes for the functional verification of wheat TaHB-PHD genes and stress-resistant molecular breeding.

Indexed as

DroughtsPlant ProteinsSalt StressTranscription FactorsTriticumDrought ResistanceGene Expression ProfilingGene Expression Regulation, PlantHaplotypesPhylogenyStress, PhysiologicalPlant ProteinsTranscription FactorsDrought-resistant haplotypeExpression patternsHB-PHDWheat

Identifiers

PMID42271227
PMCPMC13474801

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.