Evidence map›Paper›PMID 42271217›Full record

ArticleBMC plant biology2026

Dynamics of H3K4me3 and H3K36me3 histone modifications in response to powdery mildew infection in common wheat.

Guoliang Chen, Shaoshuai Liu, Ziying Wang, Yuqing Che, Tianhua Chen, Zhongyin Deng, Dada Cui, Xinyu Zou, Wanxin Xu, Xingchen Kong and 6 more

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In one paragraph

Article in BMC plant biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Guoliang Chen *College of Agronomy, Sichuan Agricultural University, Chengdu, 610106, China.
Shaoshuai Liu *State Key Laboratory of Crop Gene Resources and Breeding and National Key Facility for Crop Resources and Genetic Improvement, Institute of Crop Sciences, Chinese Academy of Agricultural Sciences, Beijing, 100081, China.
Ziying Wang *State Key Laboratory of Crop Gene Resources and Breeding and National Key Facility for Crop Resources and Genetic Improvement, Institute of Crop Sciences, Chinese Academy of Agricultural Sciences, Beijing, 100081, China.
Yuqing CheState Key Laboratory of Crop Gene Resources and Breeding and National Key Facility for Crop Resources and Genetic Improvement, Institute of Crop Sciences, Chinese Academy of Agricultural Sciences, Beijing, 100081, China.
Tianhua ChenState Key Laboratory of Crop Gene Resources and Breeding and National Key Facility for Crop Resources and Genetic Improvement, Institute of Crop Sciences, Chinese Academy of Agricultural Sciences, Beijing, 100081, China.
Zhongyin DengState Key Laboratory of Crop Gene Resources and Breeding and National Key Facility for Crop Resources and Genetic Improvement, Institute of Crop Sciences, Chinese Academy of Agricultural Sciences, Beijing, 100081, China.
Dada CuiState Key Laboratory of Crop Gene Resources and Breeding and National Key Facility for Crop Resources and Genetic Improvement, Institute of Crop Sciences, Chinese Academy of Agricultural Sciences, Beijing, 100081, China.
Xinyu ZouState Key Laboratory of Crop Gene Resources and Breeding and National Key Facility for Crop Resources and Genetic Improvement, Institute of Crop Sciences, Chinese Academy of Agricultural Sciences, Beijing, 100081, China.
Wanxin XuState Key Laboratory of Crop Gene Resources and Breeding and National Key Facility for Crop Resources and Genetic Improvement, Institute of Crop Sciences, Chinese Academy of Agricultural Sciences, Beijing, 100081, China.
Xingchen KongState Key Laboratory of Crop Gene Resources and Breeding and National Key Facility for Crop Resources and Genetic Improvement, Institute of Crop Sciences, Chinese Academy of Agricultural Sciences, Beijing, 100081, China.
Huabao ChenCollege of Agronomy, Sichuan Agricultural University, Chengdu, 610106, China.
Junshan QiInstitute of Plant Protection, Shandong Academy of Agricultural Sciences, Jinan, 250100, China.
Long MaoState Key Laboratory of Crop Gene Resources and Breeding and National Key Facility for Crop Resources and Genetic Improvement, Institute of Crop Sciences, Chinese Academy of Agricultural Sciences, Beijing, 100081, China.
Aili LiState Key Laboratory of Crop Gene Resources and Breeding and National Key Facility for Crop Resources and Genetic Improvement, Institute of Crop Sciences, Chinese Academy of Agricultural Sciences, Beijing, 100081, China. liaili@caas.cn.
Shuaifeng GengState Key Laboratory of Crop Gene Resources and Breeding and National Key Facility for Crop Resources and Genetic Improvement, Institute of Crop Sciences, Chinese Academy of Agricultural Sciences, Beijing, 100081, China. gengshuaifeng@caas.cn.
Min ZhangCollege of Agronomy, Sichuan Agricultural University, Chengdu, 610106, China. yalanmin@126.com.

Funding

CAAS Agricultural Science and Technology Innovation Program CAAS-ZDRW202002National Key R&D Program of China 2024YFD1400400National Natural Science Foundation of China 32201878National Natural Science Foundation of China 32301902
6 · The paper itself

Abstract

backgroundPowdery mildew, caused by the biotrophic fungus Blumeria graminis f. sp. tritici (Bgt), is one of the major pathogens that reduces wheat yield. Epigenetic regulation underlying wheat defense against Bgt infection, however, remains poorly characterized. Here, we conducted an integrative transcriptomic and histone H3 modification analysis on wheat leaves infected by mixed races of Bgt.

resultsRNA-seq revealed extensive transcriptional reprogramming in wheat leaves upon Bgt infection, with significant changes in a number of functional genes including those associated with histone modification. CUT&Tag analysis of two key activating histone marks, H3K4me3 and H3K36me3, showed an overall decrease in both modifications after infection. Nevertheless, H3K4me3 modification was notably increased in promoter regions, whereas H3K36me3 peaks were more enriched in the genic regions, indicating that Bgt infection induced a redistribution of these active histone marks. Integrative analysis revealed that only a subset of genes exhibited concordant changes between transcriptional levels and either H3K4me3 or H3K36me3 enrichment. Defense-related genes, including TaARF4, TaWRKY19, and TaCIPK19, were consistently down-regulated at both transcriptional and histone modification levels after Bgt infection, while TaCHIT8, TaPOD, and Calreticulin (TaCRT) were up-regulated. Consistently, virus-induced gene silencing (VIGS) of TaCIPK19, TaWRKY19, and TaARF4 enhanced resistance to Bgt, whereas silencing of TaCRT and TaCHIT8 increased susceptibility.

conclusionOur integrative analysis shows that Bgt infection induces widespread transcriptional changes and alters the distribution of active histone marks, H3K4me3 and H3K36me3. Together, our results suggest that Bgt infection triggers coordinated epigenetic and transcriptional reprogramming, exemplified by defense-related genes such as TaCIPK19, TaWRKY19, and TaARF4, whose roles in wheat resistance was confirmed by VIGS assays.

Indexed as

AscomycotaHistone CodeHistonesPlant DiseasesTriticumDisease ResistanceGene Expression Regulation, PlantPlant LeavesPlant Proteinshistone H3 trimethyl Lys4HistonesPlant ProteinsHistone modificationOmicsPowdery mildewWheat

Identifiers

PMID42271217
PMCPMC13479701

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.