Evidence map›Paper›PMID 42271192›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2026

Prediction of cognitive outcome and progression to dementia using ω6-PUFA/ω3-PUFA ratio.

Víctor Andrade, Luca Kleineidam, Holger Wagner-Thelen, Tommaso Ballarini, Rafael Campos-Martin, Pamela Martino-Adami, Kumar Parijat Tripathi, Sophie Guyonnet, Bruno Vellas, Martin Scherer and 10 more

Abstract read
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In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Víctor AndradeDivision of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, Medical faculty, University of Cologne, Cologne, Germany.
Luca KleineidamDepartment of Cognitive Disorders and Old Age Psychiatry, University Hospital Bonn, Bonn, Germany.
Holger Wagner-ThelenDivision of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, Medical faculty, University of Cologne, Cologne, Germany.
Tommaso BallariniDepartment of Cognitive Disorders and Old Age Psychiatry, University Hospital Bonn, Bonn, Germany.
Rafael Campos-MartinDivision of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, Medical faculty, University of Cologne, Cologne, Germany.
Pamela Martino-AdamiDivision of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, Medical faculty, University of Cologne, Cologne, Germany.
Kumar Parijat TripathiDivision of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, Medical faculty, University of Cologne, Cologne, Germany.
Sophie GuyonnetCentre d'Epidémiologie et de Recherche en santé des Populations de Toulouse, Toulouse, France.
Bruno VellasCentre d'Epidémiologie et de Recherche en santé des Populations de Toulouse, Toulouse, France.
Martin SchererDepartment of Primary Medical Care, Center for Psychosocial Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Wolfgang MaierDepartment of Cognitive Disorders and Old Age Psychiatry, University Hospital Bonn, Bonn, Germany.
Michael PentzekMedical Faculty, Institute of General Practice, Primary Care Research, University of Duisburg-Essen, Essen, North Rhine-Westphalia, Germany.
Matthias SchmidGerman Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.
Steffi Riedel-HellerInstitute of Social Medicine, Occupational Health and Public Health, University of Leipzig, Leipzig, Germany.
Siegfried WeyererCentral Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Horst BickelDepartment of Psychiatry, Technical University, Munich, Germany.
Birgitt WieseInstitute for General Practice, Hannover Medical School, Hannover, Lower Saxony, Germany.
Sarah EgertInstitute of Nutritional and Food Sciences, Nutritional Physiology, University of Bonn, Bonn, Germany.
Michael WagnerDepartment of Cognitive Disorders and Old Age Psychiatry, University Hospital Bonn, Bonn, Germany.
Alfredo RamírezDivision of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, Medical faculty, University of Cologne, Cologne, Germany.ORCID https://orcid.org/0000-0003-4991-763X

Funding

European Union Joint Programme Neurodegenerative Disease Research (JPND) German Federal Ministry of Education and Research (BMBF) 01ED1619AEuropean Union Joint Programme Neurodegenerative Disease Research (JPND) German Federal Ministry of Education and Research (BMBF), Diet-Body-Brain (DietBB) 01EA1372DEuropean Union Joint Programme Neurodegenerative Disease Research (JPND) German Federal Ministry of Education and Research (BMBF), Diet-Body-Brain (DietBB) 01EA1410BEuropean Union Joint Programme Neurodegenerative Disease Research (JPND) German Federal Ministry of Education and Research (BMBF), Diet-Body-Brain (DietBB) 01EA1410CEuropean Union Joint Programme Neurodegenerative Disease Research (JPND) German Federal Ministry of Education and Research (BMBF), PREADAPT project 01ED2007AGerman Research Foundation (DFG) RA 1971/6-1German Research Foundation (DFG) RA1971/7-1German Research Foundation (DFG) RA 1971/8-1German Research Network on Degenerative Dementia (KNDD)German Research Network on Dementia (KND)Health Service Research Initiative 01GI0102Health Service Research Initiative 01GI0420Health Service Research Initiative 01GI0422Health Service Research Initiative 01GI0423Health Service Research Initiative 01GI0429Health Service Research Initiative 01GI0431Health Service Research Initiative 01GI0433Health Service Research Initiative 01GI0434Health Service Research Initiative 01GI0710Health Service Research Initiative 01GI0711Health Service Research Initiative 01GI0712Health Service Research Initiative 01GI0713Health Service Research Initiative 01GI0714Health Service Research Initiative 01GI0715Health Service Research Initiative 01GI0716Health Service Research Initiative 01GY1322AHealth Service Research Initiative 01GY1322BHealth Service Research Initiative 01GY1322CHealth Service Research Initiative 01GY1322DHealth Service Research Initiative 01GY1322EHealth Service Research Initiative 01GY1322FHealth Service Research Initiative 01GY1322G
6 · The paper itself

Abstract

introductionThe polyunsaturated fatty acids (PUFAs) omega-6 (ω6) and omega-3 (ω3) are linked to cognitive performance and Alzheimer's-type dementia (DAT), but ω3-PUFA supplementation offers limited benefits. We propose that the ω6-PUFA/ω3-PUFA ratio better explains cognitive decline and DAT risk.

methodsPUFA profiles were examined in the AgeCoDe cohort (n = 3327) and MAPT trial (n  = 1679). Cox and linear mixed models evaluated associations of individual PUFAs and the ω6-PUFA/ω3-PUFA ratio with DAT progression and cognitive decline. Mendelian randomization (MR) assessed genetic causal effects. The effect of ω3-PUFA on ω6-PUFA levels was analyzed.

resultsHigher ω6-PUFA/ω3-PUFA ratio increased DAT risk beyond ω3-PUFA levels alone. A baseline high (detrimental) ratio predicted faster cognitive decline, whereas longitudinal improvements slowed decline. MR supported a genetic non-causal link. Higher ω3-PUFA levels correlated with lower ω6-PUFA species. DISCUSSION: The ω6-PUFA/ω3-PUFA ratio better predicts cognitive decline and DAT progression than individual PUFAs, suggesting that dietary adjustments may help prevent dementia.

Indexed as

Alzheimer DiseaseCognitionDementiaFatty Acids, Omega-3Fatty Acids, Omega-6Disease ProgressionFemaleHumansMaleMendelian Randomization AnalysisFatty Acids, Omega-3Fatty Acids, Omega-6Alzheimer's diseasecognitionpolyunsaturated fatty acidsprevalent neurological disordersω3‐PUFAω6‐PUFA

Identifiers

PMID42271192
PMCPMC13253362

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.