ArticleThe New phytologist2026
Anthocyanin biosynthesis in blueberry is regulated by light and abscisic acid signaling via a VcABF2-miR156-VcSPL9 feedback loop.
Yicheng Wang, Junkang Zhang, Linna Chen, Ziqian Zhang, Yuhan Gu, Donglu Fang, Chong Shi, Fuliang Cao, Yaqiong Wu, Weilin Li
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In one paragraphArticle in The New phytologist, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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10 authors.
Yicheng Wang *State Key Laboratory for Development and Utilization of Forest Food Resources, Co-Innovation Center for Sustainable Forestry in Southern China, College of Forestry and Grassland, Nanjing Forestry University, Nanjing, 210037, China.ORCID https://orcid.org/0000-0002-6522-086X Junkang Zhang *State Key Laboratory for Development and Utilization of Forest Food Resources, Co-Innovation Center for Sustainable Forestry in Southern China, College of Forestry and Grassland, Nanjing Forestry University, Nanjing, 210037, China.ORCID https://orcid.org/0009-0009-4241-3843 Linna ChenState Key Laboratory for Development and Utilization of Forest Food Resources, Co-Innovation Center for Sustainable Forestry in Southern China, College of Forestry and Grassland, Nanjing Forestry University, Nanjing, 210037, China.
Ziqian ZhangState Key Laboratory for Development and Utilization of Forest Food Resources, Co-Innovation Center for Sustainable Forestry in Southern China, College of Forestry and Grassland, Nanjing Forestry University, Nanjing, 210037, China.
Yuhan GuState Key Laboratory for Development and Utilization of Forest Food Resources, Co-Innovation Center for Sustainable Forestry in Southern China, College of Forestry and Grassland, Nanjing Forestry University, Nanjing, 210037, China.
Donglu FangState Key Laboratory for Development and Utilization of Forest Food Resources, Co-Innovation Center for Sustainable Forestry in Southern China, College of Forestry and Grassland, Nanjing Forestry University, Nanjing, 210037, China.
Chong ShiState Key Laboratory for Development and Utilization of Forest Food Resources, Co-Innovation Center for Sustainable Forestry in Southern China, College of Forestry and Grassland, Nanjing Forestry University, Nanjing, 210037, China.
Fuliang CaoState Key Laboratory for Development and Utilization of Forest Food Resources, Co-Innovation Center for Sustainable Forestry in Southern China, College of Forestry and Grassland, Nanjing Forestry University, Nanjing, 210037, China.ORCID https://orcid.org/0000-0003-2332-3243 Yaqiong WuInstitute of Botany, Jiangsu Province and Chinese Academy of Sciences (Nanjing Botanical Garden Mem. Sun Yat-Sen), Jiangsu Key Laboratory for Conservation and Utilization of Plant Resources, Nanjing, 210014, China.ORCID https://orcid.org/0000-0002-7101-4413 Weilin LiState Key Laboratory for Development and Utilization of Forest Food Resources, Co-Innovation Center for Sustainable Forestry in Southern China, College of Forestry and Grassland, Nanjing Forestry University, Nanjing, 210037, China.ORCID https://orcid.org/0000-0002-7216-2776 Funding
NSFC 32302510NSFC 32572100Ruihua Nonprofit Foundation
6 · The paper itselfAbstract
The crosstalk between light and abscisic acid (ABA) signaling orchestrates fruit coloration in horticultural crops, including blueberry (Vaccinium spp.). Although the miR156-SPL module is known to post-transcriptionally regulate anthocyanin biosynthesis, its role in integrating light and ABA signaling remains elusive. In this study, we treated blueberry fruits with fluridone (Flu), an ABA biosynthesis inhibitor, which compromised the induction of anthocyanin biosynthesis by high-light (HL) intensity in the fruits. We determined that the ABA-responsive transcription factor (TF) VcABF2 participates in HL-mediated anthocyanin accumulation by transcriptionally activating VcANS expression. We determined that the low-light (LL)-induced SQUAMOSA PROMOTER BINDING PROTEIN-LIKE (SPL) TF VcSPL9 directly binds to the promoters of VcABF2, VcDFR, and VcUFGT and transcriptionally represses their expression. However, ABA treatment antagonized the negative regulatory function of VcSPL9 in anthocyanin biosynthesis. Small-RNA transcriptome analysis revealed that miR156 is targeted and activated by VcABF2. This microRNA specifically cleaves VcSPL9 transcripts to relieve VcSPL9-mediated inhibition of VcABF2, ultimately forming a feedback loop that regulates anthocyanin biosynthesis. Our findings elucidate a mechanism by which the VcABF2-miR156-VcSPL9 loop coordinates light and ABA signaling to precisely modulate anthocyanin biosynthesis in blueberry.
Indexed as
Abscisic AcidAnthocyaninsBlueberry PlantsFeedback, PhysiologicalLightMicroRNAsPlant ProteinsSignal TransductionTranscription FactorsFruitGene Expression Regulation, PlantPromoter Regions, GeneticProtein BindingPyridonesAbscisic AcidAnthocyaninsfluridoneMicroRNAsPlant ProteinsPyridonesTranscription Factorsabscisic acidanthocyaninblueberrylightmiR156VcABF2
Identifiers
PMID42271177
PMCPMC13373803
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