Evidence map›Paper›PMID 42271169›Full record

ArticleClinical endocrinology2026

Dual Metabolic Burden of Polyendocrine Metabolic Ovarian Syndrome (PMOS) and Gestational Diabetes in Pregnancy: Impact on Neonatal Anthropometry: Insights From the Born in Bradford Cohort.

Harshal A Deshmukh, Amal Rauf, Eunice Waife, Aatif Syed, Emmanuel Ssemmondo, Najeeb Shah, Thozhukat Sathyapalan

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Article in Clinical endocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in
1citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Harshal A DeshmukhDepartment of Diabetes and Endocrinology, Gold Coast University Hospital, Southport, Queensland, Australia.
Amal RaufDepartment of Diabetes and Endocrinology, Gold Coast University Hospital, Southport, Queensland, Australia.
Eunice WaifeDepartment of Academic Diabetes, Endocrinology and Metabolism, Hull York Medical School, Hull University Teaching Hospitals NHS Trust, Hull, UK.
Aatif SyedDepartment of Diabetes and Endocrinology, Gold Coast University Hospital, Southport, Queensland, Australia.
Emmanuel SsemmondoDepartment of Academic Diabetes, Endocrinology and Metabolism, Hull York Medical School, Hull University Teaching Hospitals NHS Trust, Hull, UK.
Najeeb ShahDepartment of Academic Diabetes, Endocrinology and Metabolism, Hull York Medical School, Hull University Teaching Hospitals NHS Trust, Hull, UK.ORCID https://orcid.org/0000-0001-8946-4255
Thozhukat SathyapalanDepartment of Academic Diabetes, Endocrinology and Metabolism, Hull York Medical School, Hull University Teaching Hospitals NHS Trust, Hull, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPolyendocrine metabolic ovarian syndrome (PMOS) and gestational diabetes mellitus (GDM) independently influence foetal growth, but their combined impact remains poorly characterised. This study examined the individual and joint associations of PMOS and GDM with neonatal anthropometry in a large, multi-ethnic population.

methodsWe performed a secondary analysis of 9454 singleton pregnancies from the Born in Bradford (BiB) cohort (UK, 2007-2011). Women were classified into four groups: (1) normoglycemic non-PMOS controls, (2) PMOS only, (3) GDM only and (4) PMOS + GDM. GDM was defined using NICE criteria. The primary outcome was birth weight; secondary outcomes included head circumference, mid-arm circumference and subscapular skinfold thickness. Multivariable linear regression models were used to assess associations, adjusting for maternal age, pre-pregnancy BMI and ethnicity.

resultsWomen with PMOS were younger (25.5 ± 4.6 vs. 27.3 ± 5.6 years, p < 0.001) and had higher BMI (27.9 vs. 25.9 kg/m

conclusionsBoth PMOS and GDM are independently and additively associated with lower foetal birth weight, with coexisting PMOS + GDM conferring the greatest reduction in neonatal size and adiposity. These findings highlight the compounded intrauterine metabolic stress in pregnancies in women with coexisting PMOS and GDM and underscore the importance of targeted antenatal care to mitigate intergenerational metabolic risk.

Indexed as

Diabetes, GestationalMetabolic SyndromeAdultAnthropometryBirth WeightBody Mass IndexCohort StudiesFemaleHumansInfant, NewbornPregnancy

Identifiers

PMID42271169
PMCPMC13432601

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