Evidence map›Paper›PMID 42271077›Full record

ArticleAnnals of biomedical engineering2026

Evaluation of a Simple 3D Bioengineered Model: A Step Closer to Bridging the In Vitro-In Vivo Gap in Osteosarcoma Research.

Jelena Petrovic, Ivana Banicevic, Luka Bojic, Milena Milivojevic, Radmila Jankovic, Bojana Obradovic, Jasmina Stojkovska

Abstract read
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Article in Annals of biomedical engineering, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jelena PetrovicFaculty of Technology and Metallurgy, University of Belgrade, Belgrade, Serbia.
Ivana BanicevicInnovation Center of the Faculty of Technology and Metallurgy, Belgrade, Serbia.
Luka BojicInstitute of Molecular Genetics and Genetic Engineering, University of Belgrade, Belgrade, Serbia.
Milena MilivojevicInstitute of Molecular Genetics and Genetic Engineering, University of Belgrade, Belgrade, Serbia.
Radmila JankovicFaculty of Medicine, University of Belgrade, Belgrade, Serbia.
Bojana ObradovicFaculty of Technology and Metallurgy, University of Belgrade, Belgrade, Serbia.
Jasmina StojkovskaFaculty of Technology and Metallurgy, University of Belgrade, Belgrade, Serbia. jstojkovska@tmf.bg.ac.rs.ORCID http://orcid.org/0000-0002-6732-3037

Funding

Ministarstvo Prosvete, Nauke i Tehnološkog Razvoja 451-03-136/2025-03/200135Ministarstvo Prosvete, Nauke i Tehnološkog Razvoja 451-03-136/2025-03/200287Ministarstvo Prosvete, Nauke i Tehnološkog Razvoja 451-03-137/2025-03/200135Science Fund of the Republic of Serbia 7503
6 · The paper itself

Abstract

Standard in vitro models for cancer research and anticancer drug screening are primarily based on two-dimensional (2D) cell cultures. However, these models fail to accurately replicate the complex biology of cancer, leading to significant differences in drug efficacy between in vitro and in vivo studies. Therefore, the aim of this study was to develop and evaluate a simplified, practical three-dimensional (3D) osteosarcoma cell culture model that supports tissue-like organization, based on alginate microfibers with or without embedded hydroxyapatite (HAP) to effectively bridge the in vitro-in vivo gap in osteosarcoma research and anticancer drug screening. Alginate and HAP/alginate microfibers (500-600 µm in diameter) with uniformly immobilized murine osteosarcoma K7M2-wt cells (4 × 10

Indexed as

Bone NeoplasmsCell Culture Techniques, Three DimensionalModels, BiologicalOsteosarcomaAlginatesAnimalsCell Line, TumorDoxorubicinDurapatiteGlucuronic AcidHexuronic AcidsMiceAlginatesDoxorubicinDurapatiteGlucuronic AcidHexuronic Acids3D cell culturesAlginate-based microfibersAnticancer drug screeningDoxorubicinHydroxyapatite particles

Identifiers

PMID42271077

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.