ArticleNature2026
Mutation-dependent responses to sleep and exercise in clonal haematopoiesis.
Abstract read
In one paragraph
Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Modeling the Exposome in Murine Cardiovascular Disease.JACC. Basic to translational science · 2026Review
- Molecular Abnormalities and Associated Clinical Features in Polycythemia Vera.Medical sciences (Basel, Switzerland) · 2026Review
- Sleep and exercise can limit clonal haematopoiesis clone expansion and reduce associated atherosclerosis.Nature reviews. Cardiology · 2026Article
- Can Disruption of Circadian Rhythms Be Linked to Radiation-Induced Acute Myeloid Leukaemia?Cancers · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
37 authors.
Teresa GerhardtCardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0002-6144-5279
Walter JacobCardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0001-9649-4989
Lena GaebelCardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Merlin HeiserCardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0001-5232-0688
Christopher WolframCardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0009-0002-8113-9102
Pacific HuynhCardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Tetsushi NakaoProgram in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0001-9979-2682
Bernardo Gindri Dos SantosCardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Pamela TohNash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Aaron DouglasCardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0002-8812-9575
Niki F BrisnovaliCardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Emir RadkevichHuman Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Md Mesbah UddinProgram in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0003-1846-0411
Abi G YatesCardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Annie KhamhoungCardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Nader YatimMarc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0001-5326-1624
Matteo GianeselliCardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0003-3726-3595
Máté G KissCardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0002-9215-8328
Sukanya GoswamiCardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Daniella NelsonHuman Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Rachel ChenHuman Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Darwin D'SouzaHuman Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Zhihong ChenHuman Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0001-7403-7015
Seunghee Kim-SchulzeHuman Immune Monitoring Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0003-0192-4400
Trevor FidlerCardiovascular Research Institute, University of California San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-0758-9984
Daniel EzzatProgram in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0009-0002-6850-4275
Shaan KhurshidProgram in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Alexander G BickDepartment of Medicine, Division of Genetic Medicine, Vanderbilt University, Nashville, TN, USA.ORCID http://orcid.org/0000-0001-5824-9595
Pradeep NatarajanProgram in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0001-8402-7435
Patrick T EllinorProgram in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Abha K RajbhandariNash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0002-5596-8735
Miriam MeradMarc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0002-4481-7827
Filip K SwirskiCardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0002-3163-9152
Oren CohenCardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0009-0004-2827-9063
Leigh GoedekeCardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Michael C HonigbergProgram in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0001-8630-5021
Cameron S McAlpineCardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Cameron.mcalpine@mssm.edu.ORCID http://orcid.org/0000-0002-9832-6345
Funding
Conduits: Mount Sinai Health System Translational Science HubUL1TR004419 · NCATS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Rosalind J Wright · 2022 to 2026
$46.4MThe adaptive-innate immune interactome across multiple tissues in Alzheimer's diseaseR01AG082185 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI VAHRAM HAROUTUNIAN, Donghoon Lee · 2023 to 2026
$9.0MTraining Program in NeuroscienceT32MH087004 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI GEORGE W. HUNTLEY · 2009 to 2026
$4.0MInfluence of sleep on the hematopoietic niche and atherosclerosis during agingR01HL158534 · NHLBI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI MCALPINE, CAMERON STUART · 2021 to 2025
$2.1MIschemic cardiac injury regulates sleep through an immune-mediated heart-brain axisR01HL178835 · NHLBI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Cameron Stuart McAlpine, Filip K Swirski · 2025 to 2026
$1.7MEffects of IL-1 beta inhibition on vascular inflammation in TET2 clonal hematopoiesisR01HL173028 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI Michael Honigberg, Mabel Toribio · 2025 to 2026
$1.7MMultidisciplinary Research Training in Sleep ScienceT32HL160511 · NHLBI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI INDU A AYAPPA, ANDREW W VARGA · 2023 to 2026
$1.5MElectrocardiogram-based deep learning and decision analysis to improve atrial fibrillation risk estimationK23HL169839 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI Shaan Khurshid · 2023 to 2026
$860kInfluence of sleep on hematopoietic stem cell diversity and clonality in cardiovascular diseaseR00HL151750 · NHLBI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI MCALPINE, CAMERON STUART · 2021 to 2023
$747kClonal hematopoiesis as a mediator of cardiovascular disease in women with premature menopauseK08HL166687 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI HONIGBERG, MICHAEL · 2023 to 2025
$507kAmerican Heart Association-American Stroke Association 23CDA1050571NCATS NIH HHS UL1 TR004419NHLBI NIH HHS K08 HL166687NHLBI NIH HHS K23 HL169839NHLBI NIH HHS R00 HL151750NHLBI NIH HHS R01 HL158534NHLBI NIH HHS R01 HL173028NHLBI NIH HHS R01 HL178835NHLBI NIH HHS T32 HL160511NIA NIH HHS R01 AG082185NIMH NIH HHS T32 MH087004
Abstract
Clonal haematopoiesis (CH) activates inflammation and increases the risk of atherosclerosis
Indexed as
Clonal HematopoiesisHematopoiesisMutationPhysical Conditioning, AnimalSleepAnimalsAtherosclerosisCell ProliferationClone CellsDioxygenasesDNA-Binding ProteinsDNA (Cytosine-5-)-MethyltransferasesDNA Methyltransferase 3AFemaleHematopoietic Stem CellsHumansDioxygenasesDNA-Binding ProteinsDNA (Cytosine-5-)-MethyltransferasesDNA Methyltransferase 3ADNMT3A protein, humanDnmt3a protein, mouseInterleukin-1betaJAK2 protein, humanJak2 protein, mouseJanus Kinase 2Proto-Oncogene ProteinsTET2 protein, humanTet2 protein, mouseTrp53 protein, mouseTumor Suppressor Protein p53
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.