Evidence map›Paper›PMID 42271056›Full record

ArticleNature2026

Whole-genome duplication shaped cell-type evolution in the vertebrate brain.

Yuanzhen Zhu, Shuai Zhang, Jiankai Wei, Diego Dolgetta-Garcia, Katia Jindrich, Huimin Liu, Chenggang Shi, Rongrong Pan, Yuwei Chen, Yan Xu and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Yuanzhen ZhuDepartment of Biology, University of Oxford, Oxford, UK. yuanzhen.zhu@biology.ox.ac.uk.ORCID http://orcid.org/0000-0001-5426-4704
Shuai ZhangState Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen, China.
Jiankai WeiDepartment of Biology, University of Oxford, Oxford, UK.
Diego Dolgetta-GarciaDepartment of Biology, University of Oxford, Oxford, UK.
Katia JindrichDepartment of Biology, University of Oxford, Oxford, UK.
Huimin LiuState Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen, China.
Chenggang ShiState Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen, China.
Rongrong PanState Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen, China.
Yuwei ChenState Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen, China.
Yan XuState Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen, China.
Qiye LiState Key Laboratory of Genome and Multi-Omics Technologies and Shenzhen Key Laboratory of Forensics, BGI Research, Shenzhen, China.ORCID http://orcid.org/0000-0002-5993-0312
Günter P WagnerDepartment of Ecology and Evolutionary Biology, Yale University, New Haven, CT, USA.ORCID http://orcid.org/0000-0002-3097-002X
Peter W H HollandDepartment of Biology, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0003-1533-9376
Guang LiState Key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University, Xiamen, China. guangli@xmu.edu.cn.ORCID http://orcid.org/0000-0002-5543-5349
Sebastian M ShimeldDepartment of Biology, University of Oxford, Oxford, UK. sebastian.shimeld@biology.ox.ac.uk.ORCID http://orcid.org/0000-0003-0195-7536

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The complex brains of vertebrates have more cell types than those of their closest relatives. Whole-genome duplications (WGDs) occurred during early vertebrate evolution

Indexed as

BrainEvolution, MolecularGene DuplicationGenomeLanceletsVertebratesAnimalsHumansLampreysLizardsMicePhylogenySingle-Cell AnalysisTranscription FactorsTranscriptomeTranscription Factors

Identifiers

PMID42271056
PMCPMC13489949

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.