Evidence map›Paper›PMID 42271054›Full record

ArticleNature2026

Structural basis for chaperone-guided assembly of RNA-induced silencing complex.

Young-Yoon Lee, Minseok Jeong, Hansol Lee, Daniel Lee, Jaehyun Lee, Junsun Park, V Narry Kim, Soung-Hun Roh

Abstract read
PubMed Publisher
In one paragraph

Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Flipons, Noncoding Transcripts and Retroelements: A Universal Host Defense.International journal of molecular sciences · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Young-Yoon Lee *Center for RNA Research, Institute for Basic Science (IBS), Seoul, Republic of Korea.ORCID http://orcid.org/0000-0001-6117-5240
Minseok Jeong *Center for RNA Research, Institute for Basic Science (IBS), Seoul, Republic of Korea.ORCID http://orcid.org/0009-0000-8602-4094
Hansol Lee *School of Biological Sciences, Seoul National University, Seoul, Republic of Korea.ORCID http://orcid.org/0000-0001-8725-3710
Daniel LeeCenter for RNA Research, Institute for Basic Science (IBS), Seoul, Republic of Korea.ORCID http://orcid.org/0009-0004-0331-8011
Jaehyun LeeSchool of Biological Sciences, Seoul National University, Seoul, Republic of Korea.ORCID http://orcid.org/0009-0007-5151-8159
Junsun ParkSchool of Biological Sciences, Seoul National University, Seoul, Republic of Korea.
V Narry KimCenter for RNA Research, Institute for Basic Science (IBS), Seoul, Republic of Korea. narrykim@snu.ac.kr.ORCID http://orcid.org/0000-0002-3213-4965
Soung-Hun RohSchool of Biological Sciences, Seoul National University, Seoul, Republic of Korea. shroh@snu.ac.kr.ORCID http://orcid.org/0000-0003-3851-7200

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The RNA-induced silencing complex (RISC), comprising an Argonaute (AGO) protein and a small RNA, is the central effector in RNA silencing. Small RNAs are loaded onto AGO as bulky duplexes in an HSP70- and HSP90-dependent process

Indexed as

Argonaute ProteinsHSP90 Heat-Shock ProteinsMolecular ChaperonesRNA-Induced Silencing ComplexCryoelectron MicroscopyHumansMicroRNAsModels, MolecularProtein BindingProtein DomainsProtein FoldingArgonaute ProteinsHSP90 Heat-Shock ProteinsMicroRNAsMolecular ChaperonesRNA-Induced Silencing Complex

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.