Evidence map›Paper›PMID 42271045›Full record

ArticleNature neuroscience2026

Cerebrovascular vulnerability and fibrosis in human brain aneurysms.

Jerry C Wang, Chang N Kim, Shubhang Bhalla, Lea Scherschinski, Adnan Gopinadhan, Santhosh Arul, Damian Sanchez, Tyler D Schriber, Amanda C M Apolonio, Belda Gülsuyu and 24 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

34 authors.

Jerry C Wang *Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-8535-8460
Chang N Kim *Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0001-7921-4447
Shubhang BhallaDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.
Lea ScherschinskiDepartment of Neurosurgery, Barrow Neurological Institute & St Joseph's Hospital and Medical Center, Phoenix, AZ, USA.
Adnan GopinadhanDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0009-0006-0776-5972
Santhosh ArulDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.
Damian SanchezDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.
Tyler D SchriberDepartment of Neurosurgery, Barrow Neurological Institute & St Joseph's Hospital and Medical Center, Phoenix, AZ, USA.
Amanda C M ApolonioGladstone Institute of Neurological Disease, Gladstone Institutes, San Francisco, CA, USA.
Belda GülsuyuDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.
Muhammet M ÖztürkDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.
John P AndrewsDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-8025-1525
Joseph KimDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.
Behnam Rezai JahromiDepartment of Neurosurgery, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.ORCID http://orcid.org/0000-0003-3937-2816
Mika NiemeläDepartment of Neurosurgery, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Martin LeheckaDepartment of Neurosurgery, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Aunoy PoddarDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.
Thomas WälchliBrain Vasculature and Perivascular Niche Laboratory, Department of Oncology, University College London Cancer Institute, University College London, London, UK.
Joshua S CatapanoDepartment of Neurosurgery, Barrow Neurological Institute & St Joseph's Hospital and Medical Center, Phoenix, AZ, USA.
Rajeev D SenDepartments of Neurological Surgery, Radiology, Neurology, Mechanical Engineering, and Stroke & Applied Neuroscience Center, University of Washington, Seattle, WA, USA.
Michael R LevittDepartments of Neurological Surgery, Radiology, Neurology, Mechanical Engineering, and Stroke & Applied Neuroscience Center, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0003-3612-3347
Daniel L CookeDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, USA.
Kazim NarsinhDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, USA.
Ruchira M JhaDepartment of Neurology, Barrow Neurological Institute & St Joseph's Hospital and Medical Center, Phoenix, AZ, USA.ORCID http://orcid.org/0000-0002-3047-7649
Tomoki HashimotoDepartment of Neurosurgery, Barrow Neurological Institute & St Joseph's Hospital and Medical Center, Phoenix, AZ, USA.
S Paul OhDepartment of Neurosurgery, Barrow Neurological Institute & St Joseph's Hospital and Medical Center, Phoenix, AZ, USA.
Eric J HuangDepartment of Pathology, University of California, San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-5381-3801
Edward F ChangDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0003-2480-4700
Daniel A LimDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.
Adib A AblaDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.
Andrew C YangGladstone Institute of Neurological Disease, Gladstone Institutes, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-6756-4746
Tomasz J NowakowskiDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0003-2345-4964
Michael T LawtonDepartment of Neurosurgery, Barrow Neurological Institute & St Joseph's Hospital and Medical Center, Phoenix, AZ, USA. michael.lawton@barrowbrainandspine.com.ORCID http://orcid.org/0000-0002-1887-3980
Ethan A WinklerDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA. ethan.winkler@ucsf.edu.ORCID http://orcid.org/0000-0002-7908-7107

Funding

Translational InformaticsP30CA082103 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Alan Ashworth · 1999 to 2026
$209.7M
Functional long noncoding RNAs in neural developmentR01NS124881 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DANIEL A LIM · 2022 to 2026
$3.0M
A Translational Evaluation of Sur1-Trpm4 Imaging Endophenotypes and Genetics to Direct Precision Medicine for Cerebral Edema After Traumatic Brain InjuryR01NS115815 · NINDS · ST. JOSEPH'S HOSPITAL AND MEDICAL CENTER · PI JHA, RUCHIRA MENKA · 2021 to 2025
$2.8M
Roles of aging and cellular senescence in the development of intracranial aneurysm ruptureR01AG077780 · NIA · ST. JOSEPH'S HOSPITAL AND MEDICAL CENTER · PI SATORU EGUCHI, TOMOKI HASHIMOTO · 2023 to 2026
$2.4M
Developmental Timing During Cortical DevelopmentR01NS123263 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Tomasz Nowakowski · 2022 to 2026
$2.1M
Understanding the neurodevelopmental role and mechanism of histone demethylase JMJD3R01NS112357 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LIM, DANIEL A · 2020 to 2024
$1.9M
Illumina NovaSeq 6000 Sequencing SystemS10OD028511 · OD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHOW, ERIC D · 2020 to 2020
$583k
A Single Cell and Proteomic Precision Medicine Approach to Glyburide Responsive Contusion Expansion in Severe Traumatic Brain InjuryR21NS131689 · NINDS · ST. JOSEPH'S HOSPITAL AND MEDICAL CENTER · PI JHA, RUCHIRA MENKA, KOHANBASH, GARY · 2023 to 2024
$480k
Insights from Mural Cells for Precision Medicine in Brain Arteriovenous MalformationsF31NS147788 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Jerry Wang · 2025 to 2026
$86k
BLRD VA I01 BX000252NCI NIH HHS P30 CA082103NIA NIH HHS R01 AG077780NIH HHS S10 OD028511NINDS NIH HHS F31 NS147788NINDS NIH HHS R01 NS112357NINDS NIH HHS R01 NS115815NINDS NIH HHS R01 NS123263NINDS NIH HHS R01 NS124881NINDS NIH HHS R21 NS131689
6 · The paper itself

Abstract

Brain aneurysms are a cerebrovascular disease that results in a severe type of stroke. The cell-specific molecular pathology underlying their formation and rupture is unknown. Here we profile 227,663 neurovascular cells, including 52,946 aneurysmal cells, from a total of 14 adult human brain aneurysms and 11 control vessels. Our atlas of human brain aneurysms, as well as cell-resolution spatial transcriptomics, revealed that pathological cerebrovascular remodeling occurs with the loss of structurally supportive smooth muscle cells and the emergence of activated perivascular fibroblasts, which re-populate the vascular wall and express multiple genes linked to aneurysm risk. Fibrotic changes coincide with fibroblast-myeloid cell signaling pathways and an influx of specialized macrophages that are rarely detected in non-aneurysmal cerebrovasculature and that express destabilizing vascular cell programs. Thus, we reveal an unrecognized interplay between cerebrovascular fibrosis and myeloid inflammation during disease progression, substantially advancing our understanding of the cellular drivers and mechanisms underlying this devastating cerebrovascular disease that will inform translational development.

Indexed as

Intracranial AneurysmAdultFemaleFibroblastsFibrosisHumansMaleMiddle Aged

Identifiers

PMID42271045
PMCPMC13433319

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.