Evidence map›Paper›PMID 42270967›Full record

ArticleCell biochemistry and biophysics2026

The Synthesis and Biological Activity of Series of New Polyfunctional Pyrroles with the Potential to Modulate Neuronal Viability.

Joumaa Merza, Mouhamed Alsaqati, Corinne Wills, Paul G Waddell, Mark Ashton

Abstract read
In one paragraph

Article in Cell biochemistry and biophysics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Joumaa MerzaFaculty of Sciences, Department of Chemistry, Homs University, Homs, Syria.
Mouhamed AlsaqatiSchool of Pharmacy, Faculty of Medical Sciences, Newcastle University, Newcastle-upon-Tyne, NE1 7RU, UK. MouhamedAlsaqati@newcastle.ac.uk.
Corinne WillsSchool of Natural and Environmental Sciences, Faculty of Science and Engineering, Newcastle University, Newcastle-upon-Tyne, NE1 7RU, UK.
Paul G WaddellSchool of Natural and Environmental Sciences, Newcastle University, Newcastle-upon-Tyne, NE1 7RU, UK.
Mark AshtonSchool of Pharmacy, Faculty of Medical Sciences, Newcastle University, Newcastle-upon-Tyne, NE1 7RU, UK. Mark.Ashton@ncl.ac.uk.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The polyfunctional pyrrole 3,5-dichloro-1H-pyrrole-2,4-dicarbaldehyde (2) was reacted with malononitrile and Meldrum's acid in a regioselective manner to yield derivatives (4, 5, 6, 8, 9, and 10). Compound 8 was isolated and its structure was characterised by crystallography and 1 and 2D-

Indexed as

NeuronsNeuroprotective AgentsPyrrolesAmyloid beta-PeptidesApoptosisCell Line, TumorCell SurvivalHumansAmyloid beta-PeptidesNeuroprotective AgentsPyrrolesApoptosisNeurodegenerative disordersNeurotoxicityPyrrolessubstitution; Meldrum’s acidVilsmeier reaction

Identifiers

PMID42270967
PMCPMC13585865

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.