Evidence map›Paper›PMID 42270933›Full record

ArticleExperimental & molecular medicine2026

Defective inducible T cell costimulator signalling drives neuropilin-1

Sumin Kang, Da Eun Kim, Nahyun Kim, Eunju O, Hye Jin Yoon, Yesung Joo, Sung-Wook Hong, Kwang Soon Kim

Abstract read
In one paragraph

Article in Experimental & molecular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sumin KangDepartment of Life Sciences, Pohang University of Science and Technology (POSTECH), Pohang, Republic of Korea.
Da Eun KimDepartment of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology (POSTECH), Pohang, Republic of Korea.
Nahyun KimDepartment of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology (POSTECH), Pohang, Republic of Korea.
Eunju ODepartment of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology (POSTECH), Pohang, Republic of Korea.
Hye Jin YoonDepartment of Life Sciences, Pohang University of Science and Technology (POSTECH), Pohang, Republic of Korea.
Yesung JooDepartment of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul, Republic of Korea.
Sung-Wook HongDepartment of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology (POSTECH), Pohang, Republic of Korea. hongsw@yonsei.ac.kr.ORCID http://orcid.org/0000-0001-9718-726X
Kwang Soon KimDepartment of Life Sciences, Pohang University of Science and Technology (POSTECH), Pohang, Republic of Korea. kskim27@postech.ac.kr.ORCID http://orcid.org/0000-0002-6250-1068

Funding

National Research Foundation of Korea (NRF) RS-2024-00340161National Research Foundation of Korea (NRF) RS-2024-00442483National Research Foundation of Korea (NRF) RS-2024-00509487
6 · The paper itself

Abstract

Inducible T cell costimulator (ICOS) signalling is essential for follicular helper T (Tfh) cell activation and has emerged as a therapeutic target in B cell-dependent autoimmune diseases such as systemic lupus erythematosus (SLE). However, its dual role in supporting both Foxp3

Indexed as

B-LymphocytesGerminal CenterInducible T-Cell Co-Stimulator ProteinLupus Erythematosus, SystemicLymphocyte ActivationNeuropilin-1Signal TransductionT-Lymphocytes, RegulatoryAnimalsDisease Models, AnimalInducible T-Cell Co-Stimulator LigandMiceMice, KnockoutIcos protein, mouseInducible T-Cell Co-Stimulator LigandInducible T-Cell Co-Stimulator ProteinNeuropilin-1

Identifiers

PMID42270933
PMCPMC13324385

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.