Evidence map›Paper›PMID 42270921›Full record

ArticleScientific reports2026

Intraperitoneal blue LED irradiation as a potential approach to suppress gastric cancer peritoneal dissemination in a murine model.

Kengo Kai, Takumi Ishizuka, Jin Matsumoto, Koki Shimamawari, Baljinnyam Lkham-Erdene, Toshiki Kubota, Phyu Synn Oo, Kham Mo Aung, Hirofumi Matsui, Makoto Ikenoue and 2 more

Abstract read
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In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Kengo KaiDepartment of Anatomy, Histochemistry and Cell Biology, Faculty of Medicine, University of Miyazaki, Miyazaki, 889-1692, Miyazaki, Japan.
Takumi IshizukaDepartment of Anatomy, Histochemistry and Cell Biology, Faculty of Medicine, University of Miyazaki, Miyazaki, 889-1692, Miyazaki, Japan.
Jin MatsumotoDepartment of Applied Chemistry, Faculty of Engineering, University of Miyazaki, Miyazaki, 889-2192, Miyazaki, Japan.
Koki ShimamawariDepartment of Applied Chemistry, Faculty of Engineering, University of Miyazaki, Miyazaki, 889-2192, Miyazaki, Japan.
Baljinnyam Lkham-ErdeneDepartment of Anatomy, Histochemistry and Cell Biology, Faculty of Medicine, University of Miyazaki, Miyazaki, 889-1692, Miyazaki, Japan.
Toshiki KubotaDepartment of Anatomy, Histochemistry and Cell Biology, Faculty of Medicine, University of Miyazaki, Miyazaki, 889-1692, Miyazaki, Japan.
Phyu Synn OoDepartment of Anatomy, Histochemistry and Cell Biology, Faculty of Medicine, University of Miyazaki, Miyazaki, 889-1692, Miyazaki, Japan.
Kham Mo AungDepartment of Anatomy, Histochemistry and Cell Biology, Faculty of Medicine, University of Miyazaki, Miyazaki, 889-1692, Miyazaki, Japan.
Hirofumi MatsuiFaculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, 305-8575, Ibaraki, Japan.
Makoto IkenoueDepartment of Surgery, Faculty of Medicine, University of Miyazaki, Miyazaki, 889-1692, Miyazaki, Japan.
Atsushi NanashimaDepartment of Surgery, Faculty of Medicine, University of Miyazaki, Miyazaki, 889-1692, Miyazaki, Japan.
Yoshitaka HishikawaDepartment of Anatomy, Histochemistry and Cell Biology, Faculty of Medicine, University of Miyazaki, Miyazaki, 889-1692, Miyazaki, Japan. yhishi@med.miyazaki-u.ac.jp.

Funding

Japan Society for the Promotion of Science 24K11937
6 · The paper itself

Abstract

Peritoneal dissemination remains a critical factor associated with a poor prognosis in gastric cancer. Blue light irradiation has recently been reported to exert wavelength-specific cytotoxic effects on cancer cells. This study evaluated the feasibility, safety, and antitumor efficacy of intraoperative intraperitoneal blue LED (IPBL) irradiation using a murine gastric cancer peritoneal dissemination model. BALB/c nude mice were intraperitoneally inoculated with HGC27 cells and treated with IPBL irradiation via a cylindrical fiber-optic diffuser. Tumor burden was quantitatively assessed by total tumor weight and peritoneal carcinomatosis index (PCI), and perioperative safety was evaluated by clinical findings, serum biochemistry, histopathology, and scanning electron microscopy. The total PCI was markedly reduced in the IPBL group in comparison to the control group (7.2 ± 6.9 vs. 21.3 ± 3.1, P < 0.01). No procedure-related mortality, ascites formation, or macroscopic peritoneal damage was observed. Histological analyses demonstrated preservation of the mesothelial layer, although mild submesothelial collagen deposition and mesothelial flattening were noted. These results indicate that IPBL irradiation is a feasible and well-tolerated intraoperative intervention that significantly suppresses peritoneal dissemination in a murine gastric cancer model and may serve as a promising surgical adjunct to reduce postoperative peritoneal recurrence.

Indexed as

Peritoneal NeoplasmsStomach NeoplasmsAnimalsBlue LightCell Line, TumorDisease Models, AnimalFemaleHumansMaleMiceMice, Inbred BALB CMice, NudePeritoneumXenograft Model Antitumor AssaysGastric cancerIntraperitoneal blue LED IrradiationPeritoneal dissemination

Identifiers

PMID42270921
PMCPMC13493976

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.