Evidence map›Paper›PMID 42270916›Full record

ArticleGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2026

Lens capsular accumulation of advanced glycation end products in eyes with intraocular lens dislocation.

Koji Komatsu, Atsushi Toma, Yoichiro Masuda, Masanobu Iida, Kosuke Ichihara, Ai Iwauchi, Hoshiho Kubota, Yosuke Nakazawa, Naoki Yamamoto, Masayuki Shimoda and 1 more

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In one paragraph

Article in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Koji Komatsu *Department of Ophthalmology, The Jikei University School of Medicine, 3-25-8 Nishi-shimbashi, Minato-ku, Tokyo, 105-8461, Japan.
Atsushi Toma *Department of Ophthalmology, The Jikei University School of Medicine, 3-25-8 Nishi-shimbashi, Minato-ku, Tokyo, 105-8461, Japan.
Yoichiro MasudaDepartment of Ophthalmology, The Jikei University School of Medicine, 3-25-8 Nishi-shimbashi, Minato-ku, Tokyo, 105-8461, Japan. ymasuda@jikei.ac.jp.
Masanobu IidaDepartment of Ophthalmology, The Jikei University School of Medicine, 3-25-8 Nishi-shimbashi, Minato-ku, Tokyo, 105-8461, Japan.
Kosuke IchiharaDepartment of Ophthalmology, The Jikei University School of Medicine, 3-25-8 Nishi-shimbashi, Minato-ku, Tokyo, 105-8461, Japan.
Ai IwauchiDepartment of Pathology, The Jikei University School of Medicine, Minato- ku, Tokyo, 105-8461, Japan.
Hoshiho KubotaDepartment of Pathology, The Jikei University School of Medicine, Minato- ku, Tokyo, 105-8461, Japan.
Yosuke NakazawaFaculty of Pharmacy, Keio University, Minato-ku, Tokyo, Japan.
Naoki YamamotoResearch Promotion Headquarters, Fujita Health University, Toyoake, 470-1192, Aichi, Japan.
Masayuki ShimodaDepartment of Pathology, The Jikei University School of Medicine, Minato- ku, Tokyo, 105-8461, Japan.
Tadashi NakanoDepartment of Ophthalmology, The Jikei University School of Medicine, 3-25-8 Nishi-shimbashi, Minato-ku, Tokyo, 105-8461, Japan.

Funding

Japan Society for the Promotion of Science JP25K20212
6 · The paper itself

Abstract

purposeLate in-the-bag intraocular lens (IOL) dislocation after cataract surgery has been associated with degenerative changes of the lens capsule, but the relationship between capsular degeneration and accumulation of advanced glycation end products (AGEs) remains unclear. We compared AGE accumulation in anterior lens capsules from eyes with IOL dislocation and cataract controls to clarify its clinicopathological significance.

methodsThis single-centre retrospective observational study included 11 eyes that underwent surgery for IOL dislocation (6 dead bag syndrome [DBS], 5 capsular bag dislocation [CBD]) and 11 eyes that underwent routine cataract surgery between 2022 and 2025. AGE immunofluorescence of excised anterior capsules was quantified as the AGE-positive area (µm

resultsPatients with IOL dislocation were younger than cataract controls (53.1 ± 11.3 vs. 70.1 ± 12.1 years, p = 0.007). The AGE-positive area of the lens capsule was significantly higher in the IOL dislocation group than in the cataract group (59.7 ± 21.0 µm

conclusionsEyes with IOL dislocation, particularly DBS, exhibited marked accumulation of AGEs in the anterior lens capsule. These findings suggest that AGE accumulation is associated with degenerative changes of the lens capsule and may contribute to superficial capsular peeling and deep intralamellar splitting in late in-the-bag IOL dislocation.

Indexed as

Advanced glycation end productsDead bag syndromeIntraocular lens dislocationLens capsuleLens epithelial cell

Identifiers

PMID42270916

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.