Evidence map›Paper›PMID 42270913›Full record

ArticleGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2026

FECD-like histopathological features of descemet's membrane in bullous keratopathy associated with primary angle closure.

Ami Igarashi, Sayaka Nishihata, Kyohei Fujiwara, Toshiki Shimizu, Naruki Higashise, Sora Tanaka, Satoru Yamagami, Noriko Koizumi, Naoki Okumura, Takahiko Hayashi

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In one paragraph

Article in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ami Igarashi *Division of Ophthalmology, Department of Visual Sciences, Nihon University School of Medicine, Tokyo, 173-8610, Japan.
Sayaka Nishihata *Department of Biomedical Engineering, Faculty of Life and Medical Sciences, Doshisha University, Kyotanabe, 610-0394, Japan.
Kyohei FujiwaraDivision of Ophthalmology, Department of Visual Sciences, Nihon University School of Medicine, Tokyo, 173-8610, Japan.
Toshiki ShimizuDivision of Ophthalmology, Department of Visual Sciences, Nihon University School of Medicine, Tokyo, 173-8610, Japan.
Naruki HigashiseDepartment of Biomedical Engineering, Faculty of Life and Medical Sciences, Doshisha University, Kyotanabe, 610-0394, Japan.
Sora TanakaDepartment of Biomedical Engineering, Faculty of Life and Medical Sciences, Doshisha University, Kyotanabe, 610-0394, Japan.
Satoru YamagamiDivision of Ophthalmology, Department of Visual Sciences, Nihon University School of Medicine, Tokyo, 173-8610, Japan.
Noriko KoizumiDepartment of Biomedical Engineering, Faculty of Life and Medical Sciences, Doshisha University, Kyotanabe, 610-0394, Japan.
Naoki OkumuraDepartment of Biomedical Engineering, Faculty of Life and Medical Sciences, Doshisha University, Kyotanabe, 610-0394, Japan. nokumura@mail.doshisha.ac.jp.ORCID http://orcid.org/0000-0003-2275-5263
Takahiko HayashiDivision of Ophthalmology, Department of Visual Sciences, Nihon University School of Medicine, Tokyo, 173-8610, Japan. takamed@gmail.com.ORCID http://orcid.org/0000-0001-8704-680X

Funding

Japan Society for the Promotion of Science, Japan 22K09824Japan Society for the Promotion of Science, Japan 24K12754Japan Society for the Promotion of Science, Japan JP24K12815
6 · The paper itself

Abstract

purposeTo investigate the histopathological features of Descemet's membrane (DM) in eyes with bullous keratopathy associated with primary angle closure (PAC), with or without a history of argon laser iridotomy.

methodsThis multicenter, retrospective, observational study included eyes that underwent endothelial keratoplasty for corneal endothelial failure. Eyes with clinically diagnosed Fuchs endothelial corneal dystrophy (FECD) were excluded. DM specimens excised from eyes with PAC-associated endothelial failure were flat-mounted and examined using phase-contrast microscopy. The presence and spatial distribution of corneal guttae-like changes were evaluated and compared with those of reference specimens from FECD.

resultsIn total, 13 eyes with PAC-associated endothelial failure were included in this study. Guttae-like changes were identified on the excised DM in 9 of the 13 eyes. Of these, four eyes exhibited an atypical peripheral-predominant distribution of guttae-like changes with relative sparing of the central DM, differing from the typical central-predominant pattern observed in FECD. Additionally, guttae-like changes identified in the affected eyes were not consistently accompanied by corresponding guttae in the fellow eyes.

conclusionThese findings demonstrate that excised Descemet's membranes from some eyes with endothelial failure associated with primary angle closure exhibit guttae or guttae-like changes, sometimes with an atypical distribution. These observations raise the possibility of heterogeneous underlying endothelial vulnerability and should be interpreted as hypothesis-generating.

Indexed as

Corneal guttaeDescemet’s membraneEndothelial keratoplastyFuchs endothelial corneal dystrophyPrimary angle closureShallow anterior chamber

Identifiers

PMID42270913

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.