Evidence map›Paper›PMID 42270895›Full record

ArticleScientific reports2026

Synthesis, biological evaluation and detailed computational studies of N-sulfonyl indole-based dihydrothiazoles against colorectal carcinoma.

Zahra Batool, Iqra Naseer, Şeyma Ateşoğlu, Furkan Çakır, Fahri Akbaş, Norah A Albekairi, Halil Şenol, Asif Rasool, Zahid Shafiq, Abdulrahman Alshammari

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Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Zahra BatoolInstitute of Chemical Sciences, Bahauddin Zakariya University, Multan, 60800, Pakistan.
Iqra NaseerInstitute of Chemical Sciences, Bahauddin Zakariya University, Multan, 60800, Pakistan.
Şeyma AteşoğluDepartment of Medical Biology, Institute of Health Sciences, Bezmialem Vakif University, 34093, Fatih, Istanbul, Turkey.
Furkan ÇakırDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Bezmialem Vakif University, 34093, Fatih, Istanbul, Turkey.
Fahri AkbaşDepartment of Medical Biology, Faculty of Medicine, Bezmialem Vakif University, 34093, Fatih, Istanbul, Turkey.
Norah A AlbekairiDepartment of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Post Box 2455, 11451, Riyadh, Saudi Arabia.
Halil ŞenolDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Bezmialem Vakif University, 34093, Fatih, Istanbul, Turkey. hsenol@bezmialem.edu.tr.
Asif RasoolSchool of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210093, China.
Zahid ShafiqInstitute of Chemical Sciences, Bahauddin Zakariya University, Multan, 60800, Pakistan. zahidshafiq@bzu.edu.pk.
Abdulrahman AlshammariDepartment of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Post Box 2455, 11451, Riyadh, Saudi Arabia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A novel series of N-sulfonyl indole-based dihydrothiazole hybrids (5a-5u) was synthesized and comprehensively evaluated as potential anticancer agents against colorectal carcinoma. All compounds were structurally confirmed by NMR and HRMS and screened for cytotoxicity against HCT-116 colorectal cancer cells, with selectivity evaluated using CCD-1076Sk normal fibroblasts. Several derivatives displayed significantly higher potency than sorafenib, with compound 5d emerging as the lead molecule (IC

Indexed as

Antineoplastic AgentsColorectal NeoplasmsIndolesThiazolesHCT116 CellsHumansMolecular Docking SimulationMolecular Dynamics SimulationStructure-Activity RelationshipTumor Necrosis Factor-alphaAntineoplastic AgentsIndolesThiazolesTumor Necrosis Factor-alphaColorectal carcinomaDihydrothiazolesMolecular dockingMolecular dynamicsN-sulfonyl-indole

Identifiers

PMID42270895
PMCPMC13263351

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.