ReviewMolecular neurobiology2026
The Role of PINK1/Parkin-Mediated Mitophagy in Cerebral Ischemia-Reperfusion Injury: A Review of Recent Advances.
Review in Molecular neurobiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
7 authors.
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Abstract
Mitophagy, the selective clearance of damaged mitochondria, is a critical mechanism for mitochondrial quality control in cerebral ischemia-reperfusion injury (CIRI). The PINK1/Parkin signaling pathway is the primary ubiquitin-dependent pathway mediating mitochondrial autophagy, and its functional status directly influences the pathological progression of CIRI. This review systematically examines the molecular activation mechanisms of PINK1/Parkin-mediated mitophagy in CIRI and analyzes its interactions with core pathological processes, including oxidative stress, calcium homeostasis disruption, ferroptosis, and neuroinflammation. Furthermore, we summarize the latest advances over the past 5 years in modern medical strategies, traditional Chinese medicine interventions, and gene and protein-targeted therapies directed at this pathway. By integrating existing evidence, this review is aimed at deepening our understanding of the molecular mechanisms underlying CIRI and providing a theoretical foundation for developing novel neuroprotective therapies that target this pathway.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.