Anticancer activity and molecular docking of active ingredients from ethanolic extract of grapefruit peels against HepG2 cell.

Emad A Shalaby, Ahmed M Aboul-Enein, Mariam M Soliman, Soha S Mostafa, Nourhan A Aboelnaga, Clara R Azzam

Abstract read

In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

MnFeFoods (Basel, Switzerland) · 2026
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Emad A ShalabyDepartment of Biochemistry, Faculty of Agriculture, Cairo University, Giza, 12613, Egypt.ORCID http://orcid.org/0000-0003-2900-4833

Ahmed M Aboul-EneinDepartment of Biochemistry, Faculty of Agriculture, Cairo University, Giza, 12613, Egypt.ORCID http://orcid.org/0000-0002-3350-3451

Mariam M SolimanFaculty of Agriculture, Biotechnology Program, Cairo University, Giza, 12613, Egypt.

Soha S MostafaDepartment of Microbiology, Soils, Water and Environment Research Institute, ARC, Giza, 12619, Egypt.ORCID http://orcid.org/0000-0002-0396-0774

Nourhan A AboelnagaGenetics Department, Faculty of Agaric, Ain Shams University, P.O. Box 68, Hadayek Shoubra, 11241, Cairo, Egypt.

Clara R AzzamDepartment of Cell Research, Field Crops Research Institute, ARC, Giza, 12619, Egypt. clara.azzam@arc.sci.eg.ORCID http://orcid.org/0000-0002-4528-5236

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Natural products are vital sources for drug discovery, offering greater structural diversity than synthetic chemicals. They have historically contributed to the identification of bioactive molecules and continue to play a crucial role in the discovery of new therapeutics. Citrus species, members of the Rutaceae family, represent one of the most economically important fruit tree crops worldwide, with a global yield of approximately 123 million tons in 2010. grapefruit peels were collected, dried and their active ingredients were extracted with 70% ethanol. The resulting extracts underwent phytochemical screening. The anticancer activity of the extracts was evaluated using the MTT assay, with cell viability assessed and IC₅₀ values determined. Promising fractions were further analyzed using high-performance liquid chromatography (HPLC). Results Phytochemical screening revealed high phenolic and flavonoid content, with naringenin being the most abundant compound, followed by chlorogenic acid and ferulic acid. The extract exhibited significant anticancer activity against HepG2 cells, with an IC

Indexed as

Antineoplastic Agents, PhytogenicCitrus paradisiPlant ExtractsCell SurvivalEthanolFlavanonesFlavonoidsHep G2 CellsHumansMolecular Docking SimulationAntineoplastic Agents, PhytogenicEthanolFlavanonesFlavonoidsnaringeninPlant ExtractsGrapefruit peelHepG2 cell lineNaringeninNatural productsViability

Identifiers

PMID42270871

DOI10.1038/s41598-026-56458-w

PMCPMC13254148

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.