A model to estimate spleen volume from palpated spleen length in patients with myelofibrosis.

Albert Assad, Sue Erickson-Viitanen, J E Hamer-Maansson, Evan Braunstein, Peter Langmuir

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Article in Annals of hematology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Albert AssadIncyte Corporation, 1801 Augustine Cut-Off, Wilmington, DE, 19803, USA. aassad@incyte.com.ORCID http://orcid.org/0009-0008-3705-0585

Sue Erickson-ViitanenIncyte Corporation, 1801 Augustine Cut-Off, Wilmington, DE, 19803, USA.

J E Hamer-MaanssonIncyte Corporation, 1801 Augustine Cut-Off, Wilmington, DE, 19803, USA.

Evan BraunsteinIncyte Corporation, 1801 Augustine Cut-Off, Wilmington, DE, 19803, USA.ORCID http://orcid.org/0000-0001-5072-7636

Peter LangmuirIncyte Corporation, 1801 Augustine Cut-Off, Wilmington, DE, 19803, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Spleen volume is commonly assessed in clinical trials involving patients with myelofibrosis (MF), but direct measurement requires radiologic imaging. In routine clinical settings, spleen length measured by palpation is frequently used as an alternative measure. As the relationship between spleen length and spleen volume is not strictly proportional, interpretation of palpation-based measurements may be variable. In this post hoc analysis, we examined the relationship between palpable spleen length and spleen volume in patients with MF using pooled data from two phase 3 clinical studies. Palpable spleen length and patient weight, height, age, and sex were evaluated using mixed-model regression to identify variables associated with spleen volume. A regression model incorporating palpable spleen length and patient height provided the best fit for predicting spleen volume. The model presented here defines a quantitative relationship between palpable spleen length and spleen volume and provides a standardized reference for relating these measurements in research and observational contexts.

Indexed as

Models, StatisticalPrimary MyelofibrosisSpleenSplenomegalyAdultAgedAged, 80 and overBody HeightClinical Trials, Phase III as TopicFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedOrgan SizeReference ValuesClinical trialMyelofibrosisRegression analysisSplenomegaly

Identifiers

PMID42270854

DOI10.1016/j.clml.2017.05.015

PMCPMC13486005

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.