Evidence map›Paper›PMID 42270825›Full record

ArticleScientific reports2026

Gingival expression of MMP-1, MMP-9, and HBD-3 in healthy individuals and patients with moderate to severe chronic periodontitis.

Mahya Ramezani, Mahsa Bazargan, Mandana Sattari

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Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Mahya RamezaniDepartment of immunology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Mahsa BazarganDepartment of immunology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Mandana SattariDepartment of immunology, Shahid Beheshti University of Medical Sciences, Tehran, Iran. mandana.sattari@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Periodontitis arises from dysregulated host-microbe interactions, driving progressive tissue degradation. Matrix metalloproteinases (MMPs) and antimicrobial peptides like human β-defensin-3 (HBD-3) serve as pivotal biomarkers in periodontal pathogenesis. This study quantified gingival mRNA expression of MMP-1, MMP-9, and HBD-3 across health, gingivitis, and chronic periodontitis to assess their diagnostic and therapeutic relevance. Gingival biopsies were collected from 23 healthy controls (probing depth [PD] < 3 mm), 18 gingivitis patients, and 19 moderate-to-severe chronic periodontitis patients (PD > 5 mm). RNA extraction utilized FavorPrep™ kits, followed by cDNA synthesis and quantitative real-time PCR (qRT-PCR) with GAPDH normalization. Gene expression was calculated via the 2

Indexed as

beta-DefensinsChronic PeriodontitisGingivaMatrix Metalloproteinase 1Matrix Metalloproteinase 9AdultBiomarkersCase-Control StudiesFemaleHumansMaleMiddle Agedbeta-DefensinsBiomarkersDEFB103A protein, humanMatrix Metalloproteinase 1Matrix Metalloproteinase 9MMP1 protein, humanMMP9 protein, humanChronic periodontitisGingival biomarkersHost-response mediatorsHuman beta defensin-3Matrix metalloproteinase-1

Identifiers

PMID42270825
PMCPMC13347047

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.