Green and applicable chromatographic approaches for the estimation of a multi-component cold and flu relief formulation along with in-vitro dissolution profiling.

Mona Nabil, Hoda M Marzouk, Samah S Abbas, Hayam M Lotfy, Nancy W Nashat

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Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Mona NabilPostgraduate program, in Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Cairo University, Kasr El-Aini Street, Cairo, 11562, Egypt.

Hoda M MarzoukPharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Cairo University, Kasr El-Aini Street, Cairo, 11562, Egypt. hodaallah.marzouk@pharma.cu.edu.eg.

Samah S AbbasPharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Cairo University, Kasr El-Aini Street, Cairo, 11562, Egypt.

Hayam M LotfyPharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Cairo University, Kasr El-Aini Street, Cairo, 11562, Egypt.

Nancy W NashatPharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Cairo University, Kasr El-Aini Street, Cairo, 11562, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The emergence of novel pharmaceutical formulations requires the establishment of a reliable analytical method that can accurately quantify active ingredients for use in diverse quality control applications. An over-the-counter pharmaceutical combination of phenylephrine hydrochloride (PHE), chlorpheniramine maleate (CPM), and ibuprofen (IBU) is formulated to treat allergy, lessen fever, and relieve congestion. Two efficient and applicable liquid chromatographic methodologies were established, with an emphasis on ecological sustainability while preserving analytical precision and accuracy, in addition system suitability parameters were successfully determined for each method. The first approach involved high-performance thin-layer chromatography (HPTLC) combined with densitometric quantification, employing silica gel HPTLC 60 F

Indexed as

ChlorpheniramineIbuprofenPhenylephrineChemistry, PharmaceuticalChromatography, High Pressure LiquidChromatography, Thin LayerDrug CombinationsReproducibility of ResultsSolubilityChlorpheniramineDrug CombinationsIbuprofenPhenylephrineApplicability and sustainability assessmentChlorpheniramineCold & flu pharmaceutical formulationDissolution testingGreenness profileIbuprofenPhenylephrine.

Identifiers

PMID42270807

DOI10.1038/s41598-026-55497-7

PMCPMC13254206

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.