Article in EMBO reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Jordan Pascoe *Discipline of Microbes, Infection and Immunity, University of Surrey, Guildford, GU2 7XH, UK.
Jane Newcombe *Discipline of Microbes, Infection and Immunity, University of Surrey, Guildford, GU2 7XH, UK.
Jessica MendozaDepartment of Molecular Biology & Biochemistry, University of California Irvine, Irvine, CA, 92697, USA.ORCID 0009-0001-5135-6918
Shalini BiruaDepartment of Microbiology and Cell Biology, Indian Institute of Science, Bangalore, Karnataka, 560012, India.ORCID 0000-0003-3603-3499
Tom A MendumDiscipline of Microbes, Infection and Immunity, University of Surrey, Guildford, GU2 7XH, UK.ORCID 0000-0002-6331-2605
Kushi AnandDepartment of Microbiology and Cell Biology, Indian Institute of Science, Bangalore, Karnataka, 560012, India.ORCID 0000-0001-5929-3176
Albel SinghSchool of Biosciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK.ORCID 0000-0001-5984-226X
Amitava SinhaDepartment of Microbiology and Cell Biology, Indian Institute of Science, Bangalore, Karnataka, 560012, India.
Kadamba PapavinasasundaramDepartment of Microbiology, University of Massachusetts Chan Medical School, Worcester, MA, 01605, USA.
Apoorva BhattSchool of Biosciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK.ORCID 0000-0002-6655-1636
Gerald Larrouy-MaumusCentre for Bacterial Resistance Biology, Department of Life Sciences, Faculty of Natural Sciences, Imperial College London, London, SW7 2AZ, UK.
Amit SinghDepartment of Microbiology and Cell Biology, Indian Institute of Science, Bangalore, Karnataka, 560012, India.ORCID 0000-0001-6761-1664
Celia W GouldingDepartment of Molecular Biology & Biochemistry, University of California Irvine, Irvine, CA, 92697, USA.
Dany J V BesteDiscipline of Microbes, Infection and Immunity, University of Surrey, Guildford, GU2 7XH, UK. d.beste@surrey.ac.uk.
Funding
Vulnerabilities in Mycobacterial Cell-Wall BiogenesisP01AI095208 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI SASSETTI, CHRISTOPHER M · 2012 to 2022
$19.8M
T32 for Training in Microbiology & Infectious DiseasesT32AI141346 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI Celia Goulding, Melissa Bruckner Lodoen · 2019 to 2026
$1.0M
DBT | Rajiv Gandhi Centre for Biotechnology, Department of Biotechnology, Ministry of Science and Technology, India (RGCB) BT/PR47905/MED/29/ 1643/2023HHS | NIH | NIAID | Division of Microbiology and Infectious Diseases (DMID) AI095208HHS | NIH | NIAID | Division of Microbiology and Infectious Diseases (DMID) AI141346NIAID NIH HHS P01 AI095208NIAID NIH HHS T32 AI141346UKRI | Biotechnology and Biological Sciences Research Council (AFRC) BB/T007648/1UKRI | Biotechnology and Biological Sciences Research Council (AFRC) BB/V018159/1UKRI | MRC | Medical Research Council Centre for Medical Mycology (MRC CMM) MR/W018756/1U.S. Department of Education (ED) GAANN P200A240034
6 · The paper itself
Abstract
The evolution of new enzymatic functions is constrained and guided by the architecture of an organism's metabolic and regulatory networks and environmental constraints. Here, we identify a kinase that has evolved from pyruvate phosphate dikinase. Using biochemical and systems-level analyses, we show that this enzyme, encoded by rv1127c in Mycobacterium tuberculosis (Mtb), has diverged from its ancestral role in central carbon metabolism to function as a histidine kinase in pathogenic mycobacteria and related species. We designate this enzyme Virulence Associated DiKinase (VadK), reflecting its ability to autophosphorylate and its role in virulence. VadK is essential for the utilization of carbon sources critical for survival within the host and to cause tuberculosis (TB) in murine models. Furthermore, VadK interacts with enzymes of the methylcitrate cycle, and
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Mycobacterium tuberculosis VadK is required for the regulation of the methylcitrate cycle and virulence. · full record | OpenQuestion