Evidence map›Paper›PMID 42270755›Full record

ArticleScientific reports2026

Green synthesis of cadmium sulfide quantum dots coated with quercus infectoria and Heracleum persicum: cytotoxicity studies on RBCs and HFF-2 cells.

Negin Hashemi, Alireza Yazdinezhad, Narjes Ghaseminejad Koushali, Amirhossein Zangene Motlagh, Hossein Danafar

Abstract read
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Negin HashemiZanjan Pharmaceutical Biotechnology Research Center, Zanjan University of Medical Sciences, Zanjan, Iran.
Alireza YazdinezhadDepartment of Pharmacognosy and Traditional Pharmacy, School of Pharmacy, Zanjan University of Medical Sciences, Zanjan, Iran. Yazd1387@gmail.com.
Narjes Ghaseminejad KoushaliZanjan Pharmaceutical Biotechnology Research Center, Zanjan University of Medical Sciences, Zanjan, Iran.
Amirhossein Zangene MotlaghZanjan Pharmaceutical Biotechnology Research Center, Zanjan University of Medical Sciences, Zanjan, Iran.
Hossein DanafarZanjan Pharmaceutical Biotechnology Research Center, Zanjan University of Medical Sciences, Zanjan, Iran. danafar@zums.ac.ir.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cancer remains to be a major life-threatening illness, prompting ongoing efforts to develop innovative treatment methods. Nanotechnology presents distinct advantages by enabling targeted delivery to malignant cells while minimizing damage to surrounding healthy tissue. Quantum dots (QDs), nanoscale semiconductor particles, have emerged as promising tools for tumor imaging, diagnosis, prevention and treatment. Nonetheless, their application in biomedicine faces challenges due to cytotoxicity, which may affect normal cells and red blood cells (RBCs). To mitigate these issues, green synthesis utilizing plant extracts offers an environmentally friendly and cost-effective method to enhance biocompatibility. This study investigated the synthesis of cadmium sulfide (CdS) QDs, which were subsequently coated with ethanolic extracts from Heracleum persicum (HP) and Quercus infectoria (QI). The successful synthesis and surface modifications were verified through various techniques, including ultraviolet-visible (UV-Vis) spectroscopy, Fourier-transform infrared (FT-IR) spectroscopy, X-ray diffraction (XRD), dynamic light scattering (DLS), and scanning electron microscopy (SEM). DLS results indicated hydrodynamic sizes of 258 nm for CdS@HP and 253 nm for CdS@QI, with zeta potential values shifting from - 22.4 mV for bare CdS to - 25.0 mV for CdS@HP and - 23.9 mV for CdS@QI, suggesting enhanced colloidal stability. Biological assessments, incorporating 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) and hemolysis assays, revealed that bare CdS QDs exhibited substantial cytotoxicity and hemolytic activity. The HP-coated QDs achieved the highest cell viability and the lowest hemolysis, whereas the QI-coated QDs showed moderate protective effects but a slightly increased hemolytic response. These findings highlight the potential of plant-based coatings to improve the safety and stability of CdS QDs for future biomedical applications.

Indexed as

Cadmium CompoundsErythrocytesPlant ExtractsQuantum DotsQuercusSulfidesCell LineCell SurvivalGreen Chemistry TechnologyHemolysisHumansSpectroscopy, Fourier Transform InfraredCadmium Compoundscadmium sulfidePlant ExtractsSulfidesCancerGreen synthesisNanotechnologyPlant extractsQuantum dots

Identifiers

PMID42270755
PMCPMC13500713

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.