Evidence map›Paper›PMID 42270751›Full record

ReviewNPJ precision oncology2026

Endoplasmic reticulum stress in brain metastatic cascade.

Edgar Petrosyan, Divya Ventarapragada, Araksi Gasparyan, Grigor Gevorgyan, Samarjai Singh Naruka, Shuhua Zheng, Jawad Fares

Abstract readReview
In one paragraph

Review in NPJ precision oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Edgar Petrosyan *Department of Neurological Surgery, Northwestern University, Chicago, IL, USA. edgar.petrosyan@northwestern.edu.
Divya Ventarapragada *Medical College of Georgia, Augusta University, Augusta, GA, USA.
Araksi GasparyanYerevan State Medical University after Mkhitar Heratsi, Yerevan, Armenia.
Grigor GevorgyanCharles University, Prague, Czech Republic.
Samarjai Singh NarukaCharles University, Prague, Czech Republic.
Shuhua ZhengDepartment of Radiation Oncology; Robert H. Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Jawad FaresDepartment of Neurological Surgery, Northwestern University, Chicago, IL, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Brain metastases remain a major clinical challenge in oncology. Yet their formation is a highly selective and inefficient process in which disseminated tumor cells must survive multiple transitions, each imposing distinct cellular stresses. The endoplasmic reticulum (ER) stress response may regulate metastatic progression. Chronic reliance on ER stress signaling may create targetable vulnerabilities. This review explores ER stress as a molecular compass guiding tumor adaptation across the metastatic cascade.

Identifiers

PMID42270751
PMCPMC13594342

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.