ArticleScientific reports2026
Analgesic effects of human placental hydrolysate on capsaicin-induced hyperalgesia in rats.
Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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12 authors.
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Abstract
To explore the analgesic potential of HPH, we examined whether HPH could reduce primary and secondary hyperalgesia in a rat model of capsaicin-induced pain and whether co-administration with dexamethasone could provide enhanced analgesia with fewer side effects. HPH was administered in capsaicin-induced pain model. Primary and secondary hyperalgesia were assessed using von Frey filaments. Voltage-sensitive dye imaging (VSDI) was conducted in spinal cord slices to examine neuronal excitability. Immunohistochemistry was performed to evaluate c-Fos and phosphorylated PKCε (p-PKCε) expression. Body weight was monitored as an indicator of corticosteroid-associated side effects in rats treated with dexamethasone alone or in combination with HPH. HPH dose-dependently attenuated capsaicin-induced both primary and secondary hyperalgesia, suppressed spinal dorsal horn hyperactivity, and reduced expression of c-Fos and p-PKCε. Combination of HPH with low-dose dexamethasone produced analgesia comparable to high-dose dexamethasone while reducing corticosteroid-related weight loss, as reflected by body weight loss. HPH effectively alleviated capsaicin-induced neurogenic inflammatory pain and enhanced the therapeutic profile of dexamethasone. Co-treatment with low-dose dexamethasone may provide synergistic analgesic benefits while minimizing side effect, supporting HPH as a promising adjunctive therapy for corticosteroid-based pain management.
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