Evidence map›Paper›PMID 42270740›Full record

ArticleScientific reports2026

Comprehensive genomic analysis of avian Escherichia coli from Noakhali uncovers multidrug resistance, metal resistance, and zoonotic signatures.

Md Habib Ullah Masum, Kazi Chamonara, Mohammad Sharif Uddin, Imam Hossain, Suhag Chandra Roy, Md Imam Hossain, Md Razib Hosen, Afifa Siddiqua, Abdullah Al Mukarrom

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Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

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No citing paper in PubMed yet.

4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

9 authors.

Md Habib Ullah Masum *Department of Genomics and Bioinformatics, Faculty of Biotechnology and Genetic Engineering, Chattogram Veterinary and Animal Sciences University (CVASU), Khulshi-4225, Chattogram, Bangladesh.
Kazi Chamonara *Department of Environmental Biotechnology, Faculty of Biotechnology and Genetic Engineering, Chattogram Veterinary and Animal Sciences University (CVASU), Khulshi-4225, Chattogram, Bangladesh.
Mohammad Sharif Uddin *Department of Microbiology, Noakhali Science and Technology University (NSTU), Noakhali-3814, Noakhali, Bangladesh. sharif.mbg@nstu.edu.bd.
Imam HossainDepartment of Microbiology, Noakhali Science and Technology University (NSTU), Noakhali-3814, Noakhali, Bangladesh. ihossain.mbg@nstu.edu.bd.
Suhag Chandra RoyDepartment of Microbiology, Noakhali Science and Technology University (NSTU), Noakhali-3814, Noakhali, Bangladesh.
Md Imam HossainDepartment of Microbiology, Noakhali Science and Technology University (NSTU), Noakhali-3814, Noakhali, Bangladesh.
Md Razib HosenDepartment of Microbiology, Noakhali Science and Technology University (NSTU), Noakhali-3814, Noakhali, Bangladesh.
Afifa SiddiquaDepartment of Physiology, Biochemistry and Pharmacology, Chattogram Veterinary and Animal Sciences University (CVASU), Khulshi-4225, Chattogram, Bangladesh.
Abdullah Al MukarromMicrobiology, Healthcare Pharmaceuticals Limited, Dhaka-1205, Dhaka, Bangladesh.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Colibacillosis caused by avian pathogenic Escherichia coli (APEC) results in significant poultry losses and financial constraints globally, particularly in Bangladesh, emphasizing the urgent need for effective surveillance and control strategies. The present study employed whole-genome sequencing (WGS) of E. coli isolates from avian hosts and their surroundings to obtain genomic and evolutionary insights. Subsequently, the strains exhibited high genome completeness (> 99%) and coarse consistency scores (> 98) for genome assembly metrics. Further, genome annotation profiles showed a broad range of antimicrobial resistance (AMR) determinants, including resistance-nodulation-division (RND), major facilitator superfamily (MFS), and small multidrug resistance (SMR) multidrug efflux pumps. The coexistence of such AMR determinants within mobile genetic elements (MGEs) indicates a pattern of horizontal gene transfer and a possible dissemination pathway for the multidrug resistance phenotype. Several virulence-associated gene (VAG) clusters in the genomes suggest potential virulence profiles. A significant number of genes conferring heavy metal resistance and detoxification were identified in the genomes, including arsenic, copper, magnesium, tellurite, and zinc resistance, indicating extensive metal stress tolerance in the strains. Subsequent pangenome and phylogeny analyses uncovered significant similarities between strains derived from avian and human clinical isolates, suggesting a potential for zoonotic transmission. The findings highlight genetic association and potential public health implications of APEC and environmental E. coli (EEC) strains from poultry.

Indexed as

Drug Resistance, Multiple, BacterialEscherichia coliEscherichia coli InfectionsGenome, BacterialAnimalsAnti-Bacterial AgentsBangladeshChickensGenomicsHumansPhylogenyPoultry DiseasesWhole Genome SequencingAnti-Bacterial AgentsBangladeshMetal resistanceMultidrug resistanceWhole genome sequencingZoonotic potential

Identifiers

PMID42270740
PMCPMC13500551

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