Evidence map›Paper›PMID 42270709›Full record

ArticleScientific reports2026

Antioxidant, antimicrobial, and AMPA receptor modulatory activities of selected medicinal plant extracts reveal multitarget pharmacological potential.

Mohammad Qneibi, Belal Rahhal, Nidal Jaradat, Mohammed Hawash, Mohammad Qadi, Linda Issa, Sally Rajab, Yasmeen Feras, Nataly Bairat, Sosana Bdir and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Mohammad QneibiDepartment of Biomedical Sciences and Basic Clinical Skills, Faculty of Medicine and Allied Health Sciences, An-Najah National University, Nablus, Palestine.
Belal RahhalDepartment of Biomedical Sciences and Basic Clinical Skills, Faculty of Medicine and Allied Health Sciences, An-Najah National University, Nablus, Palestine. belalrahhal@najah.edu.
Nidal JaradatDepartment of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, An- Najah National University, Nablus, Palestine.
Mohammed HawashDepartment of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, An- Najah National University, Nablus, Palestine.
Mohammad QadiDepartment of Biomedical Sciences and Basic Clinical Skills, Faculty of Medicine and Allied Health Sciences, An-Najah National University, Nablus, Palestine.
Linda IssaDepartment of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, An- Najah National University, Nablus, Palestine.
Sally RajabDepartment of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, An- Najah National University, Nablus, Palestine.
Yasmeen FerasDepartment of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, An- Najah National University, Nablus, Palestine.
Nataly BairatDepartment of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, An- Najah National University, Nablus, Palestine.
Sosana BdirDepartment of Biomedical Sciences and Basic Clinical Skills, Faculty of Medicine and Allied Health Sciences, An-Najah National University, Nablus, Palestine.
Mohammad BdairDepartment of Biomedical Sciences and Basic Clinical Skills, Faculty of Medicine and Allied Health Sciences, An-Najah National University, Nablus, Palestine.
Samia Ammar AldwaikDepartment of Biomedical Sciences and Basic Clinical Skills, Faculty of Medicine and Allied Health Sciences, An-Najah National University, Nablus, Palestine.
Samer MudalalNutrition and Food Technology Program, Department of Agricultural Engineering, Faculty of Veterinary Medicine and Agricultural Engineering, An-Najah National University, Nablus, Palestine. samer.mudalal@najah.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The increasing prevalence of neurodegenerative and metabolic illnesses worldwide demands innovative treatment approaches. Medicinal plants having known traditional usage, such as Terminalia chebula, Portulaca oleracea, and Artemisia judaica, are abundant in bioactive chemicals. The purpose of this study is to examine their potential as natural remedies by examining their phytochemical composition and multi-target biological activity. Both qualitative and quantitative phytochemical evaluations were performed on the aqueous extracts of the chosen plants. In vitro tests such as DPPH radical scavenging for antioxidant activity, α-amylase and pancreatic lipase inhibition assays for metabolic effects, antimicrobial microdilution testing, and electrophysiological whole-cell patch-clamp recordings to measure modulation of AMPA receptor subunits were used to assess their biological activities. T. chebula showed the greatest quantities of these compounds. T. chebula exhibited the strongest antioxidant activity (DPPH IC₅₀ = 13.64 µg/mL), considerable α-amylase inhibition (IC₅₀ = 60.11 µg/mL), and moderate pancreatic lipase inhibition (IC₅₀ = 468.52 µg/mL) in vitro bioassays, suggesting strong anti-diabetic and anti-obesity capability. The effects of A. judaica and P. oleracea were less pronounced. According to antimicrobial examination, T. chebula and A. judaica shown significant broad-spectrum activity against Candida albicans, Gram-positive, and Gram-negative bacteria. Using whole-cell patch-clamp electrophysiological tests, it was shown that all extracts were antagonists of AMPA receptor subunits (GluA1, GluA2, GluA1/2, GluA2/3), with T. chebula showing the most potent inhibitory action. According to this study, Terminalia chebula is the most effective extract, exhibiting notable multi-target bioactivity against neurological, microbiological, and metabolic targets. The findings support its long-standing application and emphasize its potential as a source of new medicinal compounds. Incorporating these results supports the ongoing investigation of plant extracts in contemporary drug research.

Indexed as

Anti-Infective AgentsAntioxidantsPlant ExtractsPlants, MedicinalReceptors, AMPAalpha-AmylasesHumansLipaseMicrobial Sensitivity Testsalpha-AmylasesAnti-Infective AgentsAntioxidantsLipasePlant ExtractsReceptors, AMPAAMPA receptorAntilipaseAntioxidantArtemisia judaicaPortulaca oleraceaTerminalia chebulaα-Amylase

Identifiers

PMID42270709
PMCPMC13494046

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.