Evidence map›Paper›PMID 42270696›Full record

ArticleScientific reports2026

Reduced sensitivity to tactile stimuli associated with physical and mental disorders: A monozygotic twin study.

Saito Sakaguchi, Yusuke Morito, Masashi Konyo, Dousatsu Sakata, Kanako Akada, Mikio Watanabe, Norio Sakai, Yusuke Hara, Osaka Twin Research Group

Abstract readTwin Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Saito SakaguchiMIRAI Technology Institute, Shiseido Co., Ltd., Yokohama, Japan. saito.sakaguchi@shiseido.com.
Yusuke MoritoMIRAI Technology Institute, Shiseido Co., Ltd., Yokohama, Japan.
Masashi KonyoGrad. Sch. of Information Sciences, Tohoku University, Sendai, Japan.
Dousatsu SakataCenter for Twin Research, Graduate School of Medicine, The University of Osaka, Osaka, Japan.
Kanako AkadaCenter for Twin Research, Graduate School of Medicine, The University of Osaka, Osaka, Japan.
Mikio WatanabeCenter for Twin Research, Graduate School of Medicine, The University of Osaka, Osaka, Japan.
Norio SakaiCenter for Twin Research, Graduate School of Medicine, The University of Osaka, Osaka, Japan.
Yusuke HaraMIRAI Technology Institute, Shiseido Co., Ltd., Yokohama, Japan.
Osaka Twin Research Group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tactile sensitivity is crucial for perceiving subtle external stimuli and maintaining a high quality of life. While individual differences in tactile sensitivity are influenced by local factors, such as skin condition and nerve density, the relationships between tactile sensitivity and systemic factors, such as physical and mental health, remain unclear. This study investigated how systemic conditions are related to tactile sensitivity, excluding genetic influences, by analyzing 25 pairs of monozygotic (MZ) twins. Tactile thresholds were measured using suction stimuli on the cheek and compared with psychophysiological data from questionnaires and objective measurements. The results revealed that 18 twin pairs presented similar thresholds, indicating a genetic influence. However, in 7 twin pairs with differing thresholds, reduced tactile sensitivity was associated with greater physical and mental disorders, such as fatigue and anxiety. These findings suggest that tactile sensitivity is influenced not only by genetic factors but also by systemic health conditions that are shaped by lifestyle. Furthermore, impaired tactile sensitivity may reflect broader physical and mental health issues, making it a potential marker for preventive health interventions. This study provides insights into the complex interplay between tactile perception and systemic health, paving the way for tactile interventions aimed at enhancing the quality of life.

Indexed as

Mental DisordersTouchTouch PerceptionTwins, MonozygoticAdultFemaleHumansMaleMiddle AgedPhysical StimulationQuality of LifeSensory ThresholdsEnvironmental factorsMonozygotic designQuality of lifeSensory informationTactile perceptionTactile sensitivity

Identifiers

PMID42270696
PMCPMC13500838

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.