Evidence map›Paper›PMID 42270626›Full record

ArticleNature communications2026

Photoinduced H-Bonding EDA complex-enabled skeletal editing of furans to pyridazines.

Juan Tang, Pingyao Gan, Wenjing Li, Lin Peng, Guiyu Yang, Yuying He, Shikun Zhou, Ting Long, Chong Tian, Haiyan Fu and 1 more

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Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Juan TangCollege of New Energy Materials and Chemistry, Leshan Normal University, Leshan, Sichuan, 614000, P. R. China.
Pingyao GanKey Laboratory of Green Chemistry & Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu, Sichuan, 610064, P. R. China.
Wenjing LiSchool of pharmacy, Xi'an Medical University, Xi'an, 710021, China.
Lin PengCollege of New Energy Materials and Chemistry, Leshan Normal University, Leshan, Sichuan, 614000, P. R. China.
Guiyu YangCollege of New Energy Materials and Chemistry, Leshan Normal University, Leshan, Sichuan, 614000, P. R. China.
Yuying HeCollege of New Energy Materials and Chemistry, Leshan Normal University, Leshan, Sichuan, 614000, P. R. China.
Shikun ZhouCollege of New Energy Materials and Chemistry, Leshan Normal University, Leshan, Sichuan, 614000, P. R. China.
Ting LongCollege of New Energy Materials and Chemistry, Leshan Normal University, Leshan, Sichuan, 614000, P. R. China.
Chong TianCollege of New Energy Materials and Chemistry, Leshan Normal University, Leshan, Sichuan, 614000, P. R. China.
Haiyan FuKey Laboratory of Green Chemistry & Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu, Sichuan, 610064, P. R. China. scufhy@scu.edu.cn.ORCID http://orcid.org/0000-0002-7185-2062
Shun LiCollege of New Energy Materials and Chemistry, Leshan Normal University, Leshan, Sichuan, 614000, P. R. China. lishun@lsnu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Skeletal editing enables direct structural reorganization of molecular frameworks, providing a powerful strategy for rapid exploration of chemical space in lead optimization. Herein we report a mild, photoinduced skeletal editing strategy that converts furans into pharmacologically valuable pyridazines without external photocatalysts. Upon photoexcitation, the H-bonding electron donor-acceptor (EDA) complex formed between furan and hexafluoroisopropanol (HFIP) enables activation of molecular oxygen, generating reactive oxygen species that promote oxidative ring opening of furan to a 1,4-dicarbonyl intermediate, which subsequently condenses with hydrazine hydrate to afford pyridazines. The method displays broad substrate scope, tolerates complex and drug-derived motifs, and can be implemented to continuous-flow processing with enhanced efficiency and scalability.

Identifiers

PMID42270626
PMCPMC13402322

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.