Evidence map›Paper›PMID 42270510›Full record

ReviewTrends in cancer2026

Mitochondrial transfer reveals an organellar layer of cancer ecology.

Derick Okwan-Duodu, Bo Li, Edgar Engleman

Abstract readReview
In one paragraph

Review in Trends in cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Derick Okwan-DuoduDepartment of Pathology, Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA, USA. Electronic address: dokwan@stanford.edu.
Bo LiDepartment of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Edgar EnglemanDepartment of Pathology, Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA, USA.

Funding

Targeting Lymph Node Dependent Immune Tolerance in CancerR01CA251174 · NCI · STANFORD UNIVERSITY · PI EDGAR G. ENGLEMAN · 2021 to 2026
$3.2M
High dimensional atlas of circulating neutrophils as reporters of solid organ functional statusR01ES034235 · NIEHS · STANFORD UNIVERSITY · PI OKWAN-DUODU, DERICK · 2021 to 2025
$2.1M
NCI NIH HHS R01 CA251174NIEHS NIH HHS R01 ES034235
6 · The paper itself

Abstract

Tumors are ecological systems shaped by continuous exchange with surrounding cells. The transfer of functional mitochondria, which reprograms malignant behavior, introduces a distinct layer to this ecology. Cancer evolution may proceed not solely through mutation and selection but also through the horizontal assimilation of organellar traits acquired from neighboring cells.

Indexed as

MitochondriaNeoplasmsAnimalsHumansMutationcancer hallmarksmetabolismmetastasismitochondrial transferorganellar ecology

Identifiers

PMID42270510
PMCPMC13386575

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.