ArticleInternational journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group2026
Verification and validation in canine cadaver of an MPI-integrable RF head coil for magnetic particle hyperthermia.
Article in International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Design, verification and validation of a spatially confined magnetic nanoparticle thermal therapy device for conformal thermal dose contouring.International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group · 2026Article
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Authors and funding
9 authors.
Funding
Abstract
purposeMagnetic particle hyperthermia (MPH), the mild heating of solid tumors with magnetic nanoparticles, is an emerging treatment modality used as an adjuvant to therapies such as ionizing radiation. MPH can be paired with magnetic particle imaging (MPI) hardware to improve thermal treatment planning, spatially confined heating, and thermal dose delivery. In this work, we describe the design, verification, and validation of a radiofrequency (RF) head coil designed to integrate into a clinical MPI scanner.
methodsThe RF coil was designed to accommodate an adult human head, provide a homogeneous (±10%) field along a 10 cm axial centerline, generate a peak magnetic flux density of 10 mT at 100 kHz, and be MPI compliant. Verification of the design consisted of a combination of magnetic field and nanoparticle heating measurements. To validate an MPI/MPH imaging and heating workflow, a canine cadaver was surgically prepared by implanting magnetic nanoparticles in the brain, followed by anatomical imaging, MPI, and heating with the head coil. To explore if the measured performance can be generalized to human treatment, we conducted a virtual MPH treatment of a human glioma.
resultsCoil performance verification demonstrated RF fields as high as
conclusionsWe successfully constructed, verified, and validated an MPI-compatible RF head coil for combined MPI/MPH therapy.
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