ArticleJournal of neuromuscular diseases2026
Time-efficient coronal MRI reflects clinical and pathological features of myopathies.
Article in Journal of neuromuscular diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Traditional axial view-based skeletal muscle MRI is valuable for detecting pathological changes but is time-consuming. This study validated a novel time-efficient coronal view-based muscle MRI protocol and a semiquantitative visual scoring system as a practical alternative for evaluating hereditary (HM) and inflammatory myopathies (IM). Using coronal short tau inversion recovery (STIR) and T1-weighted sequences, we assessed edema and fatty infiltration in 102 subjects, including patients with HM, IM, and healthy controls. To verify diagnostic reliability, a plane-to-plane comparison (coronal vs. axial) was performed in the thigh muscles, demonstrating excellent agreement between visual scores (ICC > 0.9, Kappa > 0.79). Clinically, higher visual fat scores in HM correlated significantly with muscle weakness (p < 0.001) and older age, while higher edema scores in IM correlated with weakness (p = 0.013) and female sex. Histopathologically, MRI fat scores correlated with internal nucleation and Oil Red O staining (p < 0.001), whereas edema scores correlated with fiber necrosis (p < 0.001), regeneration, and interstitial fibrosis (p < 0.001). This novel coronal protocol offers a validated, high-throughput alternative enabling wide anatomical coverage in significantly less time, with visual scores that strongly correlate with clinical status and histopathology, supporting its utility as a biomarker for disease monitoring.
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