ReviewJournal of molecular biology2026
Microglial ITAM & ITIM Signaling in Neurodegenerative Disease and Brain Aging.
Review in Journal of molecular biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- NKR-P1A/CD161: A Multifunctional Immune Receptor at the Crossroads of Antitumor Immunity.Biomolecules · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Innate immunity within the central nervous system (CNS) plays key roles in shaping both healthy brain aging and vulnerability to neurodegenerative disease. Microglia, the tissue-resident macrophages of the CNS, play a key role in mediating the innate immune responses to age-associated pathologies. A growing body of literature details the roles of microglia in responding to white matter degeneration, misfolded proteins, and cell death. These functions depend on cell-surface receptors that enable microglia to sample and react to changes in their environment. Recent studies highlight the importance of receptors associated with immunoreceptor tyrosine-based activation and inhibitory motifs (ITAMs/ITIMs) in pathological brain aging. In this review, we describe how ITAM/ITIM-associated receptors and their downstream signaling pathways shape microglial responses to neurodegenerative disease and aging. A deeper understanding of microglial activation and resolution may provide tools to harness these cells' capacity to maintain and extend neurological healthspan.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.