Trial reportJournal of clinical periodontology2026
A Fasting-Mimicking Diet Affects the Inflammatory Response Following Periodontal Treatment: A Multi-centre Feasibility Randomised Controlled Pilot Trial.
Trial report in Journal of clinical periodontology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors.
Funding
Abstract
aimTo investigate whether cycles of fasting-mimicking diet (FMD), used as an adjunct to non-surgical periodontal treatment, are feasible and could influence clinical and inflammatory responses, particularly with respect to C-reactive protein (CRP). MATERIALS AND
methodsIndividuals with periodontitis were randomised to receive steps 1 and 2 of periodontal treatment, either following their regular diet (controls) or with three adjunctive 5-day courses of FMD (test). Blood and gingival crevicular fluid (GCF) samples were collected to study the levels of inflammatory biomarkers, along with clinical parameters and patient-reported outcome measurements (PROMs). All patients were followed up at days 1, 7, 45, 90 and 180 post treatment, and food diaries were completed. Exploratory repeated measures ANOVA and non-parametric tests were used.
resultsTwenty-seven patients completed the 6-month follow-up. Feasibility criteria were satisfied. Baseline serum high-sensitivity (hs)-CRP increased on Day 1 in both groups and then decreased. Exploratory longitudinal analyses indicated temporal changes in hs-CRP and selected GCF biomarkers (including MMP-8, CRP, IL-6, IL-1α and IL-1β), with descriptive trends towards lower values at later time points in the FMD group observed for hs-CRP, MMP-8 and IL-6. No inter-group periodontal clinical differences were detected. Only minimal adverse events were reported in the FMD group, with no inter-group differences in PROMs and clinical outcomes.
conclusionThree cycles of FMD, adjunctive to step 2, were associated with a reduction of the inflammatory response after subgingival instrumentation, although these changes did not benefit clinical parameters. Given the exploratory nature of the analyses and the multiple comparisons performed, these findings should be interpreted with caution.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.